CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. * CATALYTIC ACTIVITY: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. * CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. * PATHWAY: NECESSARY FOR THE BIOSYNTHESIS OF PURINES, THYMYDYLATE, METHIONINE, HISTIDINE, PANTOTHENATE, AND FORMYL TRNA-MET. * SUBUNIT: Homodimer. * SUBCELLULAR LOCATION: Cytoplasmic. * TISSUE SPECIFICITY: PRESENT IN ALL TISSUES. * DISEASE: DEFECTS IN MTHFD1 SEEM TO BE ASSOCIATED WITH ELEVATED RISK FOR NEURAL TUBE DEFECTS (NTD) SUCH AS SPINA BIFIDA. * MISCELLANEOUS: THIS TRIFUNCTIONAL ENZYME CONSISTS OF TWO MAJOR DOMAINS: AN AMINOTERMINAL PART, CONTAINING THE METHYLENE-THF DEHYDROGENASE AND THE METHENYL-THF CYCLOHYDROLASE ACTIVITIES AND A LARGER FORMYL-THF SYNTHETASE DOMAIN. * SIMILARITY: IN THE N-TERMINAL SECTION; TO OTHER DEHYDROGENASE/ CYCLOHYDROLASE ENZYMES OR DOMAINS. * SIMILARITY: IN THE C-TERMINAL SECTION; STRONG TO OTHER FORMYLTETRAHYDROFOLATE SYNTHETASE DOMAINS OR ENZYMES. |
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25-JAN-03
Last Update 13-Mar-03