FUNCTION : Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers. SUBUNIT : ASSOCIATES WITH BETA-CATENIN. TISSUE SPECIFICITY : Ubiquitous. PTM : Phosphorylation on Ser-38 inhibits the actin-binding ability of fascin. SIMILARITY : BELONGS TO THE FASCIN FAMILY. |
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27-Feb-03
Last Update 13-Mar-03