FUNCTION: FORMS A CHANNEL THROUGH THE MITOCHONDRIAL OUTER MEMBRANE THAT ALLOWS DIFFUSION OF SMALL HYDROPHILIC MOLECULES. THE CHANNEL ADOPTS AN OPEN CONFORMATION AT LOW OR ZERO MEMBRANE POTENTIAL AND A CLOSED CONFORMATION AT POTENTIALS ABOVE 30-40 MV. THE OPEN STATE HAS A WEAK ANION SELECTIVITY WHEREAS THE CLOSED STATE IS CATION-SELECTIVE. * SUBCELLULAR LOCATION: Outer mitochondrial membrane. * ALTERNATIVE PRODUCTS: 4 isoforms; 1 (shown here), 2, 3 and 4; are produced by alternative splicing. * TISSUE SPECIFICITY: EXPRESSED IN ALL TISSUES EXAMINED. * DOMAIN: CONSISTS MAINLY OF MEMBRANE-SPANNING SIDED BETA-SHEETS. * SIMILARITY: BELONGS TO THE EUKARYOTIC MITOCHONDRIAL PORIN FAMILY. |
|
25-JAN-03
Last Update 13-Mar-03