FUNCTION: FORMS A CHANNEL THROUGH THE MITOCHONDRIAL OUTER MEMBRANE AND ALSO THE PLASMA MEMBRANE. THE CHANNEL ALLOWS DIFFUSION OF SMALL HYDROPHILIC MOLECULES; IT ADOPTS AN OPEN CONFORMATION AT LOW OR ZERO MEMBRANE POTENTIAL AND A CLOSED CONFORMATION AT POTENTIALS ABOVE 30-40 MV. THE OPEN STATE HAS A WEAK ANION SELECTIVITY WHEREAS THE CLOSED STATE IS CATION-SELECTIVE. * SUBCELLULAR LOCATION: OUTER MEMBRANE OF MITOCHONDRIA AND PLASMA MEMBRANE. * TISSUE SPECIFICITY: HEART, LIVER, AND SKELETAL MUSCLE. * DOMAIN: CONSISTS MAINLY OF MEMBRANE-SPANNING SIDED BETA-SHEETS. * SIMILARITY: BELONGS TO THE EUKARYOTIC MITOCHONDRIAL PORIN FAMILY. |
|
25-JAN-03
Last Update 13-Mar-03