CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone phosphate. * PATHWAY: Plays an important role in several metabolic pathways. * SUBUNIT: Homodimer. * DISEASE: TPI DEFICIENCY IS THE MOST SEVERE CLINICAL DISORDER OF GLYCOLYSIS. IT IS ASSOCIATED WITH NEONATAL JAUNDICE, CHRONIC HEMOLYTIC ANEMIA, PROGRESSIVE NEUROMUSCULAR DYSFUNCTION, CARDIOMYOPATHY, AND INCREASED SUSCEPTIBILITY TO INFECTION. TPI DEFICIENCY IS AN AUTOSOMAL RECESSIVE DISORDER. * SIMILARITY: BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY. FUNCTION: CONJUGATION OF REDUCED GLUTATHIONE TO A WIDE NUMBER OF EXOGENOUS AND ENDOGENOUS HYDROPHOBIC ELECTROPHILES. * CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione. * SUBUNIT: Homodimer. * SUBCELLULAR LOCATION: Cytoplasmic. * TISSUE SPECIFICITY: THIS IS A LIVER ISOZYME. * POLYMORPHISM: THERE ARE TWO ALLELES; GSTM1A AND GSTM1B WHICH DIFFER IN POSITION 172. * SIMILARITY: BELONGS TO THE GST SUPERFAMILY. MU FAMILY. |
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25-JAN-03
Last Update 13-Mar-03