FUNCTION: INVOLVED IN CELL ADHESION. MAY BE INVOLVED IN THE ATTACHMENT OF THE ACTIN-BASED MICROFILAMENTS TO THE PLASMA MEMBRANE. * SUBUNIT: EXHIBITS SELF-ASSOCIATION PROPERTIES. * SUBCELLULAR LOCATION: CYTOPLASMIC FACE OF ADHESION PLAQUES. * ALTERNATIVE PRODUCTS: 2 isoforms; 1/vinculin and 2/metavinculin (shown here); are produced by alternative splicing. Metavinculin differs from vinculin by the insertion of a 68 residues domain near the C-terminus. * TISSUE SPECIFICITY: METAVINCULIN IS MUSCLE-SPECIFIC. * PTM: PHOSPHORYLATED ON SERINES, THREONINES AND TYROSINES AND ACYLATED BY MYRISTIC ACID AND/OR PALMITIC ACID. * SIMILARITY: STRONG, TO OTHER VINCULINS AND TO ALPHA-CATENINS. |
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10-DEC-02
Last Update 13-Mar-03