FUNCTION: TYPE II REGULATORY CHAINS MEDIATE MEMBRANE ASSOCIATION BY BINDING TO ANCHORING PROTEINS, INCLUDING THE MAP2 KINASE. * SUBUNIT: THE INACTIVE FORM OF THE ENZYME IS COMPOSED OF TWO REGULATORY CHAINS AND TWO CATALYTIC CHAINS. ACTIVATION BY CAMP PRODUCES TWO ACTIVE CATALYTIC MONOMERS AND A REGULATORY DIMER THAT BINDS FOUR CAMP MOLECULES. * TISSUE SPECIFICITY: FOUR TYPES OF REGULATORY CHAINS ARE FOUND: I-ALPHA, I-BETA, II-ALPHA, AND II-BETA. THEIR EXPRESSION VARIES AMONG TISSUES AND IS IN SOME CASES CONSTITUTIVE AND IN OTHERS INDUCIBLE. * PTM: PHOSPHORYLATED BY THE ACTIVATED CATALYTIC CHAIN. * SIMILARITY: CONTAINS 2 CYCLIC NUCLEOTIDE-BINDING DOMAINS. * SIMILARITY: BELONGS TO THE CAMP-DEPENDENT KINASE REGULATORY CHAIN FAMILY. |
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04-JAN-03
Last Update 13-Mar-03