|FUNCTION: Binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
* ALTERNATIVE PRODUCTS: 2 isoforms; 1 (shown here) and 2; may be produced by alternative splicing.
* DOMAIN: THE MOLECULE IS IN A COILED COIL STRUCTURE. THE SEQUENCE EXHIBITS A PROMINENT SEVEN-RESIDUES PERIODICITY.
* SIMILARITY: BELONGS TO THE TROPOMYOSIN FAMILY.
* DATABASE: NAME=Atlas Genet. Cytogenet. Oncol. Haematol.; WWW="http://www.infobiogen.fr/services/chromcancer/Genes/TPM4ID359.html".
Last Update 13-Mar-03