|FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
* SUBUNIT: Homohexamer.
* ALTERNATIVE PRODUCTS: 2 isoforms; 1 (shown here) and 2; may be produced by alternative splicing.
* DISEASE: SERA FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS OFTEN CONTAIN ANTIBODIES THAT REACT WITH THE KI ANTIGEN.
* SIMILARITY: BELONGS TO THE PA28 FAMILY.
Last Update 13-Mar-03