|FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
* CATALYTIC ACTIVITY: N-acetylneuraminate + phosphate = N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O.
* CATALYTIC ACTIVITY: N-acetylneuraminate 9-phosphate + phosphate = N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O.
* TISSUE SPECIFICITY: Ubiquitous.
* SIMILARITY: CONTAINS 1 AFP-LIKE DOMAIN.
Last Update 13-Mar-03