FUNCTION: MAJOR ROLE IN THE SYNTHESIS OF NUCLEOSIDE TRIPHOSPHATES OTHER THAN ATP. * CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. * SUBUNIT: HEXAMER OF TWO DIFFERENT CHAINS: A AND B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). * SUBCELLULAR LOCATION: Nuclear and cytoplasmic. * PTM: The N-terminus is blocked. * DISEASE: THIS PROTEIN IS FOUND IN REDUCED AMOUNT IN TUMOR CELLS OF HIGH METASTASIC POTENTIAL. SOMATIC MUTATIONS OF NME1 ARE FOUND IN NEUROBLASTOMA. * SIMILARITY: BELONGS TO THE NDK FAMILY. |
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18-JUL-00
Last Update 13-Mar-03