FUNCTION: BINDS TO FOLATE AND REDUCED FOLIC ACID DERIVATIVES AND MEDIATES DELIVERY OF 5-METHYLTETRAHYDROFOLATE TO THE INTERIOR OF CELLS. * SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor. * ALTERNATIVE PRODUCTS: 2 isoforms; 1/GPI-anchored (shown here) and 2/Cytoplasmic; are produced by alternative splicing. * TISSUE SPECIFICITY: FR-ALPHA LEVELS ARE GREATLY ELEVATED IN A VARIETY OF MALIGNANT TISSUES OF EPITHELIAL ORIGIN COMPARED WITH NORMAL TISSUES. * PTM: EIGHT DISULFIDE BONDS ARE PRESENT (PROBABLE). * SIMILARITY: BELONGS TO THE FOLATE RECEPTOR FAMILY. |
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31-JUL-00
Last Update 13-Mar-03