FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH KINASES. * SUBUNIT: Homodimer. * SUBCELLULAR LOCATION: Cytoplasmic. * ALTERNATIVE PRODUCTS: 2 isoforms; a long form (shown here) and a short form; may be produced by alternative initiation. * TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES. * PTM: ISOFORM ALPHA DIFFERS FROM ISOFORM BETA IN BEING PHOSPHORYLATED (BY SIMILARITY). * SIMILARITY: BELONGS TO THE 14-3-3 FAMILY. |
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22-SEP-00
Last Update 13-Mar-03