SUBUNIT: HETEROTETRAMER OF TWO TYPE I AND TWO TYPE II KERATINS. KERATIN 18 ASSOCIATES WITH KERATIN 8. * DISEASE: DEFECTS IN KRT18 ARE TO BE A PREDISPOSITION OF CRYPTOGENIC CIRRHOSIS (CC). * MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). * SIMILARITY: BELONGS TO THE INTERMEDIATE FILAMENT FAMILY. |
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06-DEC-01
Last Update 13-Mar-03