FUNCTION: Component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. May have a rotamase activity. May play a role in the intracellular trafficking of hetero-oligomeric forms of steroid hormone receptors. * CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). * SUBUNIT: Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-coA alpha-hydroxylase (PHYH). * SUBCELLULAR LOCATION: Nuclear and cytoplasmic. * TISSUE SPECIFICITY: Widely expressed. * PTM: Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). * SIMILARITY: BELONGS TO THE FKBP-TYPE PPIASE FAMILY. * SIMILARITY: CONTAINS 2 FKBP-TYPE PPIASE DOMAINS. * SIMILARITY: CONTAINS 3 TPR REPEATS. |
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06-JAN-01
Last Update 13-Mar-03