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NiceProt View of Swiss-Prot: O00299

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name CLI1_HUMAN
Primary accession number O00299
Secondary accession number Q15089
Entered in Swiss-Prot in Release 36, July 1998
Sequence was last modified in Release 40, October 2001
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Chloride intracellular channel protein 1
Synonyms Nuclear chloride ion channel 27
NCC27
p64 CLCP
Chloride channel ABP
Gene name
CLIC1 or NCC27
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Lymphoma;
MEDLINE=97284733; PubMed=9139710; [NCBI, ExPASy, EBI, Israel, Japan]
Valenzuela S.M., Martin D.K., Por S.B., Robbins J.M., Warton K., Bootcov M.R., Schofield P.R., Campbell T.J., Breit S.N.;
"Molecular cloning and expression of a chloride ion channel of cell nuclei.";
J. Biol. Chem. 272:12575-12582(1997).
[2]
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Thymus;
Noh Y.H., Hahn M.J.;
"Cloning and sequence analysis of the gene encoding the xxx-binding protein.";
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[3]
SEQUENCE FROM NUCLEIC ACID.
MEDLINE=99208773; PubMed=10191309; [NCBI, ExPASy, EBI, Israel, Japan]
Chuang J.Z., Milner T.A., Zhu M., Sung C.H.;
"A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.";
J. Neurosci. 19:2919-2928(1999).
[4]
SEQUENCE FROM NUCLEIC ACID.
Rowen L., Madan A., Qin S., Shaffer T., James R., Ratcliffe A., Abbasi N., Dickhoff R., Loretz C., Madan A., Dors M., Young J., Lasky S., Hood L.;
"Sequence of the human major histocompatibility complex class III region.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[5]
SEQUENCE FROM NUCLEIC ACID.
Shiina S., Tamiya G., Oka A., Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[6]
SEQUENCE OF 32-241 FROM NUCLEIC ACID.
Hillier L., Clark N., Dubuque T., Elliston K., Hawkins M., Holman M., Hultman M., Kucaba T., Le M., Lennon G., Marra M., Parsons J., Rifkin L., Rohlfing T., Soares M., Tan F., Trevaskis E., Waterston R., Williamson A., Wohldmann P., Wilson R.;
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
[7]
X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
MEDLINE=21576145; PubMed=11551966; [NCBI, ExPASy, EBI, Israel, Japan]
Harrop S.J., DeMaere M.Z., Fairlie W.D., Reztsova T., Valenzuela S.M., Mazzanti M., Tonini R., Qiu M.R., Jankova L., Warton K., Bauskin A.R., Wu W.M., Pankhurst S., Campbell T.J., Breit S.N., Curmi P.M.G.;
"Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.";
J. Biol. Chem. 276:44993-45000(2001).
Comments
  • FUNCTION: SEEMS TO ACT AS A CHLORIDE ION CHANNEL.
  • SUBCELLULAR LOCATION: MOSTLY IN THE NUCLEUS INCLUDING IN THE NUCLEAR MEMBRANE. SMALL AMOUNT IN THE CYTOPLASM AND THE PLASMA MEMBRANE.
  • SIMILARITY: BELONGS TO THE CLIC FAMILY OF CHLORIDE CHANNELS.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
U93205; AAC25675.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF034607; AAD20437.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF109197; AAD26137.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF129756; AAD18073.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP000504; BAB63376.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
X87689; CAA61020.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
PDB
1K0M; 12-DEC-01.[ExPASy / RCSB]
1K0N; 12-DEC-01.[ExPASy / RCSB]
1K0O; 12-DEC-01.[ExPASy / RCSB]
Detailed list of linked structures.
Genew HGNC:2062; CLIC1.
CleanEx HGNC:2062; CLIC1.
MIM 602872 [NCBI / EBI].
GeneCards CLIC1.
GeneLynx CLIC1; Homo sapiens.
SOURCE CLIC1; Homo sapiens.
Ensembl O00299; Homo sapiens. [Entry / Contig view]
InterPro IPR004046; GST_Cterm.
IPR004045; GST_Nterm.
IPR002946; Int_Cl_channel.
Graphical view of domain structure.
Pfam PF00043; GST_C; 1.
PRINTS PR01263; INTCLCHANNEL.
TIGRFAMs TIGR00862; O-ClC; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O00299.
ProtoNet O00299.
ProtoMap O00299.
PRESAGE O00299.
DIP O00299.
ModBase O00299.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Ionic channel; Ion transport; Chloride channel; Chloride; Voltage-gated channel; Nuclear protein; 3D-structure.
Features
KeyFrom  To Length Description
CONFLICT   63   63        Q -> E (IN REF. 1 AND 3).
SEVIEWER logo Feature table viewer
Sequence information
Length: 241 AA Molecular weight: 26922 Da CRC64: 163EEB7481826A0A [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL 



K 

O00299 in FASTA format

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