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NiceProt View of Swiss-Prot: O00571
[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name DDX3_HUMAN
Primary accession number O00571
Secondary accession number O15536
Entered in Swiss-Prot in Release 36, July 1998
Sequence was last modified in Release 40, October 2001
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name DEAD-box protein 3
Synonyms Helicase-like protein 2
HLP2
DEAD-box, X isoform
Gene name
DDX3 or DBX
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
 SEQUENCE FROM NUCLEIC ACID.
TISSUE=Hippocampus, and Liver;
Chung J., Lee S.-G., Song K.;
"Identification of a human homolog of a putative RNA helicase gene (mDEAD3) expressed in mouse erythroid cells.";
Korean J. Biochem. 27:193-197(1995).
[2]
 SEQUENCE FROM NUCLEIC ACID.
Owsianka A.M., Patel A.H.;
"DEAD box putative RNA helicase.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[3]
 SEQUENCE FROM NUCLEIC ACID.
MEDLINE=98022381; PubMed=9381176; [NCBI, ExPASy, EBI, Israel, Japan]
Lahn B.T., Page D.C.;
"Functional coherence of the human Y chromosome.";
Science 278:675-680(1997).
[4]
 SEQUENCE FROM NUCLEIC ACID.
TISSUE=Skin;
Strausberg R.;
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[5]
 SEQUENCE OF 1-9, AND ACETYLATION.
MEDLINE=20318637; PubMed=10859333; [NCBI, ExPASy, EBI, Israel, Japan]
Yaguee J., Alvarez I., Rognan D., Ramos M., Vazquez J., Lopez de Castro J.A.;
"An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo.";
J. Exp. Med. 191:2083-2092(2000).
Comments
  • FUNCTION: PUTATIVE ATP-DEPENDENT RNA HELICASE. INTERACTS SPECIFICALLY WITH HEPATITIS C VIRUS CORE PROTEIN RESULTING A CHANGE IN INTRACELLULAR LOCATION.
  • SIMILARITY: BELONGS TO THE DEAD BOX HELICASE FAMILY. DDX3 SUBFAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
U50553; AAB95637.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF061337; AAC34298.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF000983; AAC51830.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF000982; AAC51829.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011819; AAH11819.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
HSSP Q58083; 1HV8. [HSSP ENTRY / PDB]
Genew HGNC:2745; DDX3.
CleanEx HGNC:2745; DDX3.
MIM 300160 [NCBI / EBI].
GeneCards DDX3.
GeneLynx DDX3; Homo sapiens.
SOURCE DDX3; Homo sapiens.
Ensembl O00571; Homo sapiens. [Entry / Contig view]
InterPro IPR001410; DEAD.
IPR000629; DEAD_box.
IPR001650; Helicase_C.
Graphical view of domain structure.
Pfam PF00270; DEAD; 1.
PF00271; helicase_C; 1.
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
PROSITE PS00039; DEAD_ATP_HELICASE; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O00571.
ProtoNet O00571.
ProtoMap O00571.
PRESAGE O00571.
DIP O00571.
ModBase O00571.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Helicase; ATP-binding; RNA-binding; DNA-binding; Acetylation.
Features
KeyFrom   To Length Description
INIT_MET   0     0        
NP_BIND   223   230  8     ATP (POTENTIAL).
SITE   346   349  4     DEAD BOX.
DOMAIN   581   661  81     GLY/SER-RICH.
MOD_RES   1     1        ACETYLATION.
CONFLICT   49    49        K -> R (IN REF. 3).
FT aligner logo Feature aligner
SEVIEWER logo Feature table viewer
Sequence information
Length: 661 AA Molecular weight: 73112 Da CRC64: F0F03DD8FBC00A65 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
         |          |          |          |          |          | 
SHVAVENALG LDQQFAGLDL NSSDNQSGGS TASKGRYIPP HLRNREATKG FYDKDSSGWS 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
SSKDKDAYSS FGSRSDSRGK SSFFSDRGSG SRGRFDDRGR SDYDGIGSRG DRSGFGKFER 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
GGNSRWCDKS DEDDWSKPLP PSERLEQELF SGGNTGINFE KYDDIPVEAT GNNCPPHIES 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
FSDVEMGEII MGNIELTRYT RPTPVQKHAI PIIKEKRDLM ACAQTGSGKT AAFLLPILSQ 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
IYSDGPGEAL RAMKENGRYG RRKQYPISLV LAPTRELAVQ IYEEARKFSY RSRVRPCVVY 

       310        320        330        340        350        360 
         |          |          |          |          |          | 
GGADIGQQIR DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR MLDMGFEPQI 

       370        380        390        400        410        420 
         |          |          |          |          |          | 
RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI FLAVGRVGST SENITQKVVW 

       430        440        450        460        470        480 
         |          |          |          |          |          | 
VEESDKRSFL LDLLNATGKD SLTLVFVETK KGADSLEDFL YHEGYACTSI HGDRSQRDRE 

       490        500        510        520        530        540 
         |          |          |          |          |          | 
EALHQFRSGK SPILVATAVA ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA 

       550        560        570        580        590        600 
         |          |          |          |          |          | 
TSFFNERNIN ITKDLLDLLV EAKQEVPSWL ENMAYEHHYK GSSRGRSKSS RFSGGFGARD 

       610        620        630        640        650        660 
         |          |          |          |          |          | 
YRQSSGASSS SFSSSRASSS RSGGGGHGSS RGFGGGGYGG FYNSDGYGGN YNSQGVDWWG 



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O00571 in FASTA format

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