| General information about the entry |
|
|
|
|
|
[1]
|
SEQUENCE FROM NUCLEIC ACID.
Baehr C.,
Herzog A.,
Haeussermann S.,
Marks F.,
Gschwendt M.;
"Cloning, expression, and phosphorylation by protein kinase A of human epsilon-COP.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
|
[2]
|
SEQUENCE FROM NUCLEIC ACID.
Lamerdin J.E.,
McCready P.M.,
Skowronski E.,
Adamson A.W.,
Burkhart-Schultz K.,
Gordon L.,
Kyle A.,
Ramirez M.,
Stilwagen S.,
Phan H.,
Velasco N.,
Do L.,
Regala W.,
Terry A.,
Garnes J.,
Danganan L.,
Poundstone P.,
Christensen M.,
Georgescu A.,
Avila J.,
Liu S.,
Attix C.,
Andreise T.,
Trankheim M.,
Amico-Keller G.,
Coefield J.,
Duarte S.,
Lucas S.,
Bruce R.,
Thomas P.,
Quan G.,
Kronmiller B.,
Arellano A.,
Montgomery M.,
Ow D.,
Nolan M.,
Trong S.,
Kobayashi A.,
Olsen A.S.,
Carrano A.V.;
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
|
[3]
|
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Uterus;
MEDLINE=21154917; PubMed=11230166; [NCBI, ExPASy, EBI, Israel, Japan]
Wiemann S.,
Weil B.,
Wellenreuther R.,
Gassenhuber J.,
Glassl S.,
Ansorge W.,
Boecher M.,
Bloecker H.,
Bauersachs S.,
Blum H.,
Lauber J.,
Duesterhoeft A.,
Beyer A.,
Koehrer K.,
Strack N.,
Mewes H.-W.,
Ottenwaelder B.,
Obermaier B.,
Tampe J.,
Heubner D.,
Wambutt R.,
Korn B.,
Klein M.,
Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
|
[4]
|
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Brain, Lymph, and Skin;
Strausberg R.;
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
|
|
|
|
- FUNCTION: THE COATOMER IS A CYTOSOLIC PROTEIN COMPLEX THAT BINDS TO DILYSINE MOTIFS AND REVERSIBLY ASSOCIATES WITH GOLGI NON-CLATHRIN-COATED VESICLES, WHICH FURTHER MEDIATE BIOSYNTHETIC PROTEIN TRANSPORT FROM THE ER, VIA THE GOLGI UP TO THE TRANS GOLGI NETWORK. COATOMER COMPLEX IS REQUIRED FOR BUDDING FROM GOLGI MEMBRANES, AND IS ESSENTIAL FOR THE RETROGRADE GOLGI-TO-ER TRANSPORT OF DILYSINE-TAGGED PROTEINS. IN MAMMALS, THE COATOMER CAN ONLY BE RECRUITED BY MEMBRANES ASSOCIATED TO ADP-RIBOSYLATION FACTORS (ARFS), WHICH ARE SMALL GTP-BINDING PROTEINS; THE COMPLEX ALSO INFLUENCES THE GOLGI STRUCTURAL INTEGRITY, AS WELL AS THE PROCESSING, ACTIVITY, AND ENDOCYTIC RECYCLING OF LDL RECEPTORS (BY SIMILARITY).
- SUBUNIT: OLIGOMERIC COMPLEX THAT CONSISTS OF AT LEAST THE ALPHA, BETA, BETA', GAMMA, DELTA, EPSILON AND ZETA SUBUNITS.
- SUBCELLULAR LOCATION: THE COATOMER IS CYTOPLASMIC OR POLYMERIZED ON THE CYTOPLASMIC SIDE OF THE GOLGI, AS WELL AS ON THE VESICLES/BUDS ORIGINATING FROM IT (BY SIMILARITY).
- PTM: Phosphorylated by PKA.
- SIMILARITY: BELONGS TO THE COPE FAMILY.
|
|
|
|
This SWISS-PROT entry is copyright. It is produced through a collaboration
between the Swiss Institute of Bioinformatics and the EMBL outstation -
the European Bioinformatics Institute. There are no restrictions on its
use by non-profit institutions as long as its content is in no way
modified and this statement is not removed. Usage by and for commercial
entities requires a license agreement (See http://www.isb-sib.ch/announce/
or send an email to license@isb-sib.ch).
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 20 30 40 50 60
| | | | | |
APPAPGPASG GSGEVDELFD VKNAFYIGSY QQCINEAQRV KLSSPERDVE RDVFLYRAYL
70 80 90 100 110 120
| | | | | |
AQRKFGVVLD EIKPSSAPEL QAVRMFADYL AHESRRDSIV AELDREMSRS VDVTNTTFLL
130 140 150 160 170 180
| | | | | |
MAASIYLHDQ NPDAALRALH QGDSLECTAM TVQILLKLDR LDLARKELKR MQDLDEDATL
190 200 210 220 230 240
| | | | | |
TQLATAWVSL ATGGEKLQDA YYIFQEMADK CSPTLLLLNG QAACHMAQGR WEAAEGLLQE
250 260 270 280 290 300
| | | | | |
ALDKDSGYPE TLVNLIVLSQ HLGKPPEVTN RYLSQLKDAH RSHPFIKEYQ AKENDFDRLV
LQYAPSA
|
O14579 in FASTA format |
|
ExPASy Home page
