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NiceProt View of Swiss-Prot: O14818

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name PSA7_HUMAN
Primary accession number O14818
Secondary accession numbers Q9BR53 Q9H4K5 Q9UEU8
Entered in Swiss-Prot in Release 40, October 2001
Sequence was last modified in Release 40, October 2001
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Proteasome subunit alpha type 7
Synonyms EC 3.4.25.1
Proteasome subunit RC6-1
Proteasome subunit XAPC7
Gene name
PSMA7
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
MEDLINE=96357088; PubMed=8764072; [NCBI, ExPASy, EBI, Israel, Japan]
Huang J., Kwong J., Sun E.C.-Y., Liang T.J.;
"Proteasome complex as a potential cellular target of hepatitis B virus X protein.";
J. Virol. 70:5582-5591(1996).
[2]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
TISSUE=Blood;
MEDLINE=20499367; PubMed=11042152; [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[3]
SEQUENCE FROM NUCLEIC ACID (ISOFORMS 1; 2 AND 4).
MEDLINE=21638749; PubMed=11780052; [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[4]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
TISSUE=Lung;
Strausberg R.;
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
  • CATALYTIC ACTIVITY: Cleavage at peptide bonds with very broad specificity.
  • PATHWAY: Involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway.
  • SUBUNIT: THE PROTEASOME IS COMPOSED OF AT LEAST 15 NON IDENTICAL SUBUNITS WHICH FORM A HIGHLY ORDERED RING-SHAPED STRUCTURE.
  • SUBCELLULAR LOCATION: Cytoplasmic and nuclear.
  • ALTERNATIVE PRODUCTS: 4 isoforms; 1 (shown here), 2, 3 and 4; may be produced by alternative splicing.
  • SIMILARITY: BELONGS TO PEPTIDASE FAMILY T1A.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
AF022815; AAB81515.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF054185; AAC99402.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL078633; CAC04017.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL078633; CAC04018.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL078633; CAC29253.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC004427; AAH04427.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
HSSP P40303; 1RYP. [HSSP ENTRY / PDB]
MEROPS T01.974; -.
Genew HGNC:9536; PSMA7.
CleanEx HGNC:9536; PSMA7.
MIM 606607 [NCBI / EBI].
GeneCards PSMA7.
GeneLynx PSMA7; Homo sapiens.
SOURCE PSMA7; Homo sapiens.
Ensembl O14818; Homo sapiens. [Entry / Contig view]
InterPro IPR000426; Proteasome_A.
IPR001353; Protsme_protease.
Graphical view of domain structure.
Pfam PF00227; proteasome; 1.
PROSITE PS00388; PROTEASOME_A; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O14818.
ProtoNet O14818.
ProtoMap O14818.
PRESAGE O14818.
DIP O14818.
ModBase O14818.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Proteasome; Hydrolase; Protease; Alternative splicing.
Features
KeyFrom   To Length Description
VARSPLIC   1    70        MISSING (IN ISOFORM 2).
VARSPLIC   117   166        RYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGT YHAWK ANAIGRGAK -> VGACPLACSPLAAGQSRLRHGGSCHVTS ALYAEQWAQAVWHLCPHRGFRL (IN ISOFORM 4).
VARSPLIC   167   248        MISSING (IN ISOFORM 4).
CONFLICT   160   160        A -> S (IN REF. 2).
SEVIEWER logo Feature table viewer
Sequence information
Length: 248 AA Molecular weight: 27887 Da CRC64: 5DD0276A1C2DEF91 [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE 



KKKQKKAS 

O14818 in FASTA format

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