| General information about the entry |
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[1]
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SEQUENCE FROM NUCLEIC ACID (ISOFORM B).
MEDLINE=98250059; PubMed=9590177; [NCBI, ExPASy, EBI, Israel, Japan]
Diaz E.,
Pfeffer S.R.;
"TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking.";
Cell 93:433-443(1998).
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[2]
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SEQUENCE FROM NUCLEIC ACID (ISOFORMS A AND B).
TISSUE=Placenta;
MEDLINE=99089640; PubMed=9874244; [NCBI, ExPASy, EBI, Israel, Japan]
Than N.G.,
Sumegi B.,
Than G.N.,
Kispal G.,
Bohn H.;
"Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants.";
Eur. J. Biochem. 258:752-757(1998).
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[3]
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SEQUENCE FROM NUCLEIC ACID (ISOFORMS A AND B).
TISSUE=Placenta;
MEDLINE=99322174; PubMed=10393528; [NCBI, ExPASy, EBI, Israel, Japan]
Than N.G.,
Sumegi B.,
Than G.N.,
Kispal G.,
Bohn H.;
"Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein.";
Tumour Biol. 20:184-192(1999).
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[4]
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SEQUENCE FROM NUCLEIC ACID (ISOFORM B).
TISSUE=Colon, and Muscle;
Strausberg R.;
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
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[5]
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CHARACTERIZATION.
TISSUE=Placenta;
MEDLINE=83221037; PubMed=6856484; [NCBI, ExPASy, EBI, Israel, Japan]
Bohn H.,
Kraus W.,
Winckler W.;
"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).";
Oncodev. Biol. Med. 4:343-350(1983).
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- FUNCTION: REQUIRED FOR MANNOSE 6-PHOSPHATE RECEPTORS (MPR) TRANSPORT FROM ENDOSOMES TO THE TRANS-GOLGI NETWORK.
- SUBUNIT: INTERACTS WITH CYTOPLASMIC DOMAINS OF BOTH CATION-INDEPENDENT 300 KDA AND CATION DEPENDENT 46 KDA MANNOSE 6-PHOSPHATE RECEPTORS. ISOFORM A ALSO EXISTS AS A HOMODIMER (KNOWN AS PP17C).
- SUBCELLULAR LOCATION: CYTOPLASMIC AND ON ENDOSOMES.
- ALTERNATIVE PRODUCTS: 2 isoforms; A and B (shown here); are produced by alternative splicing.
- SIMILARITY: BELONGS TO THE PERIPILIN FAMILY.
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This SWISS-PROT entry is copyright. It is produced through a collaboration
between the Swiss Institute of Bioinformatics and the EMBL outstation -
the European Bioinformatics Institute. There are no restrictions on its
use by non-profit institutions as long as its content is in no way
modified and this statement is not removed. Usage by and for commercial
entities requires a license agreement (See http://www.isb-sib.ch/announce/
or send an email to license@isb-sib.ch).
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10 20 30 40 50 60
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MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHVKTVC
70 80 90 100 110 120
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DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD
130 140 150 160 170 180
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TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR
190 200 210 220 230 240
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LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG
250 260 270 280 290 300
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SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQALSLME TVKQGVDQKL VEGQEKLHQM
310 320 330 340 350 360
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WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ
370 380 390 400 410 420
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QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP
430
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FAPGITEKAP EEKK
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O60664 in FASTA format |
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