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NiceProt View of Swiss-Prot: O75947

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name ATPQ_HUMAN
Primary accession number O75947
Secondary accession number Q9H3J4
Entered in Swiss-Prot in Release 39, May 2000
Sequence was last modified in Release 39, May 2000
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name ATP synthase D chain, mitochondrial
Synonyms EC 3.6.3.14
My032 protein
Gene name
ATP5H
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
TISSUE=Thymus;
Lee H.C., Park D.S., Lee C.M., Cho W.K., Ahn H.J., Lee M.Y., Hwang M.Y., Jin S.W., Sohn U.I.K.;
"cDNA cloning, and chromosomal localization of a human F1F0-type ATPase subunit d.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
TISSUE=Blood;
MEDLINE=20499367; PubMed=11042152; [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[3]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 2).
TISSUE=Fetal brain;
Mao Y.M., Xie Y., Ying K.;
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[4]
SEQUENCE FROM NUCLEIC ACID (ISOFORMS 1 AND 2).
TISSUE=Brain, and Pancreas;
Strausberg R.;
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: THIS IS ONE OF THE CHAINS OF THE NONENZYMATIC COMPONENT (CF(0) SUBUNIT) OF THE MITOCHONDRIAL ATPASE COMPLEX. IT HAS NO APPARENT BACTERIAL HOMOLOG AND ITS EXACT FUNCTION IS UNKNOWN.
  • CATALYTIC ACTIVITY: ATP + H2O + H+(In) = ADP + phosphate + H+(Out).
  • SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(0) SEEMS TO HAVE NINE SUBUNITS: A, B, C, D, E, F, G, F6 AND 8 (OR A6L).
  • ALTERNATIVE PRODUCTS: 2 isoforms; 1 (shown here) and 2; are produced by alternative splicing.
  • SIMILARITY: BELONGS TO THE ATPASE D CHAIN FAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
AF087135; AAC36338.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF070650; AAD20956.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF061735; AAG43146.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032245; AAH32245.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC038092; AAH38092.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
Genew HGNC:845; ATP5H.
CleanEx HGNC:845; ATP5H.
Ensembl O75947; Homo sapiens. [Entry / Contig view]
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O75947.
ProtoNet O75947.
ProtoMap O75947.
PRESAGE O75947.
DIP O75947.
ModBase O75947.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Hydrogen ion transport; CF(0); Mitochondrion; Acetylation; Alternative splicing.
Features
KeyFrom  To Length Description
INIT_MET   0    0        BY SIMILARITY.
MOD_RES   1    1        ACETYLATION (BY SIMILARITY).
VARSPLIC   73   96        MISSING (IN ISOFORM 2).
SEVIEWER logo Feature table viewer
Sequence information
Length: 160 AA Molecular weight: 18360 Da CRC64: DFCF756DA84A760D [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
AGRKLALKTI DWVAFAEIIP QNQKAIASSL KSWNETLTSR LAALPENPPA IDWAYYKANV 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
AKAGLVDDFE KKFNALKVPV PEDKYTAQVD AEEKEDVKSC AEWVSLSKAR IVEYEKEMEK 

       130        140        150        160 
         |          |          |          | 
MKNLIPFDQM TIEDLNEAFP ETKLDKKKYP YWPHQPIENL 

O75947 in FASTA format

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