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NiceProt View of Swiss-Prot: P00338

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name LDHA_HUMAN
Primary accession number P00338
Secondary accession numbers None
Entered in Swiss-Prot in Release 01, July 1986
Sequence was last modified in Release 06, January 1988
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms EC 1.1.1.27
LDH-A
LDH muscle subunit
LDH-M
Gene name
LDHA
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID.
MEDLINE=85127030; PubMed=3838278; [NCBI, ExPASy, EBI, Israel, Japan]
Tsujibo H., Tiano H.F., Li S.S.-L.;
"Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme.";
Eur. J. Biochem. 147:9-15(1985).
[2]
SEQUENCE FROM NUCLEIC ACID.
MEDLINE=86076881; PubMed=3000353; [NCBI, ExPASy, EBI, Israel, Japan]
Chung F.Z., Tsujibo H., Bhattacharyya U., Sharief F.S., Li S.S.-L.;
"Genomic organization of human lactate dehydrogenase-A gene.";
Biochem. J. 231:537-541(1985).
[3]
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Muscle;
Strausberg R.;
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[4]
VARIANT CYS-314.
MEDLINE=93075246; PubMed=1445373; [NCBI, ExPASy, EBI, Israel, Japan]
Sudo K., Maekawa M., Shioya M., Ikeda K., Takahashi N., Isogai Y., Li S.S.-L., Kanno T., Machida K., Toriumi J.;
"Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.";
Biochem. Int. 27:1051-1057(1992).
[5]
VARIANT GLU-221.
MEDLINE=94199831; PubMed=7908613; [NCBI, ExPASy, EBI, Israel, Japan]
Maekawa M., Sudo K., Kobayashi A., Sugiyama E., Li S.S.-L., Kanno T.;
"Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes.";
Clin. Chem. 40:665-668(1994).
Comments
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
X02152; CAA26088.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03077; CAA26879.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03078; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03079; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03080; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03081; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03082; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03083; CAA26879.1; JOINED.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000749; AAH00749.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001829; AAH01829.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00347; DEHULM.
HSSP P00339; 9LDT. [HSSP ENTRY / PDB]
Aarhus/Ghent-2DPAGE 2207; NEPHGE.
Genew HGNC:6535; LDHA.
CleanEx HGNC:6535; LDHA.
MIM 150000 [NCBI / EBI].
GeneCards LDHA.
GeneLynx LDHA; Homo sapiens.
SOURCE LDHA; Homo sapiens.
Ensembl P00338; Homo sapiens. [Entry / Contig view]
InterPro IPR001557; L_LDH.
IPR001236; ldh.
Graphical view of domain structure.
Pfam PF00056; ldh; 1.
PF02866; ldh_C; 1.
PRINTS PR00086; LLDHDRGNASE.
PROSITE PS00064; L_LDH; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS P00338.
ProtoNet P00338.
ProtoMap P00338.
PRESAGE P00338.
DIP P00338.
ModBase P00338.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Oxidoreductase; NAD; Glycolysis; Multigene family; Disease mutation; Polymorphism.
Features
KeyFrom   To Length Description
INIT_MET   0     0        
ACT_SITE   192   192        ACCEPTS A PROTON DURING CATALYSIS.
VARIANT   221   221        K -> E.
/FTId=VAR_004180.
VARIANT   314   314        R -> C (IN LDHA DEFICIENCY).
/FTId=VAR_004181.
SEVIEWER logo Feature table viewer
Sequence information
Length: 331 AA Molecular weight: 36557 Da CRC64: E31FEC40FD6A72D2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
ATLKDQLIYN LLKEEQTPQN KITVVGVGAV GMACAISILM KDLADELALV DVIEDKLKGE 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
MMDLQHGSLF LRTPKIVSGK DYNVTANSKL VIITAGARQQ EGESRLNLVQ RNVNIFKFII 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
PNVVKYSPNC KLLIVSNPVD ILTYVAWKIS GFPKNRVIGS GCNLDSARFR YLMGERLGVH 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
PLSCHGWVLG EHGDSSVPVW SGMNVAGVSL KTLHPDLGTD KDKEQWKEVH KQVVESAYEV 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
IKLKGYTSWA IGLSVADLAE SIMKNLRRVH PVSTMIKGLY GIKDDVFLSV PCILGQNGIS 

       310        320        330 
         |          |          | 
DLVKVTLTSE EEARLKKSAD TLWGIQKELQ F 

P00338 in FASTA format

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