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NiceProt View of Swiss-Prot: P00505
[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name AATM_HUMAN
Primary accession number P00505
Secondary accession number Q9BWA3
Entered in Swiss-Prot in Release 01, July 1986
Sequence was last modified in Release 14, April 1990
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Aspartate aminotransferase, mitochondrial [Precursor]
Synonyms EC 2.6.1.1
Transaminase A
Glutamate oxaloacetate transaminase-2
Gene name
GOT2
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
 SEQUENCE FROM NUCLEIC ACID.
MEDLINE=89087454; PubMed=3207426; [NCBI, ExPASy, EBI, Israel, Japan]
Pol S., Bousquet-Lemercier B., Pave-Preux M., Pawlak A., Nalpas B., Berthelot P., Hanoune J., Barouki R.;
"Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA.";
Biochem. Biophys. Res. Commun. 157:1309-1315(1988).
[2]
 SEQUENCE FROM NUCLEIC ACID.
TISSUE=Muscle;
Strausberg R.;
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
[3]
 SEQUENCE OF 30-430.
MEDLINE=86026367; PubMed=4052435; [NCBI, ExPASy, EBI, Israel, Japan]
Martini F., Angelaccio S., Barra D., Pascarella S., Maras B., Doonan S., Bossa F.;
"The primary structure of mitochondrial aspartate aminotransferase from human heart.";
Biochim. Biophys. Acta 832:46-51(1985).
Comments
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
M22632; AAA35568.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000525; AAH00525.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00594; XNHUDM.
A31873; A31873.
HSSP P00508; 7AAT. [HSSP ENTRY / PDB]
Genew HGNC:4433; GOT2.
CleanEx HGNC:4433; GOT2.
MIM 138150 [NCBI / EBI].
GeneCards GOT2.
GeneLynx GOT2; Homo sapiens.
SOURCE GOT2; Homo sapiens.
Ensembl P00505; Homo sapiens. [Entry / Contig view]
InterPro IPR004839; Aminotransf1/2.
IPR000796; Asptransf_sub.
IPR004838; NHtransf_1.
Graphical view of domain structure.
Pfam PF00155; aminotran_1_2; 1.
PRINTS PR00799; TRANSAMINASE.
PROSITE PS00105; AA_TRANSFER_CLASS_1; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS P00505.
ProtoNet P00505.
ProtoMap P00505.
PRESAGE P00505.
DIP P00505.
ModBase P00505.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Transferase; Aminotransferase; Pyridoxal phosphate; Mitochondrion; Transit peptide.
Features
KeyFrom   To Length Description
TRANSIT   1    29  29     MITOCHONDRION.
CHAIN   30   430  401     ASPARTATE AMINOTRANSFERASE.
BINDING   279   279        PYRIDOXAL PHOSPHATE (BY SIMILARITY).
CONFLICT   110   111        AE -> EA (IN REF. 3).
CONFLICT   255   255        D -> N (IN REF. 3).
CONFLICT   305   305        E -> Q (IN REF. 3).
CONFLICT   346   346        G -> V (IN REF. 2).
CONFLICT   428   428        V -> A (IN REF. 2).
SEVIEWER logo Feature table viewer
Sequence information
Length: 430 AA [This is the length of the unprocessed precursor] Molecular weight: 47475 Da [This is the MW of the unprocessed precursor] CRC64: B449577AA35DAF2A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEV 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
LKSGRFVTVQ TISGTGALRI GASFLQRFFK FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
YYDPKTCGFD FTGAVEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE 

       310        320        330        340        350        360 
         |          |          |          |          |          | 
AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKGMADR IIGMRTQLVS 

       370        380        390        400        410        420 
         |          |          |          |          |          | 
NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI YMTKDGRISV AGVTSSNVGY 

       430 
         | 
LAHAIHQVTK
P00505 in FASTA format

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