CATALYTIC ACTIVITY : ATP + pyruvate = ADP + phosphoenolpyruvate. COFACTOR : REQUIRES MAGNESIUM AND POTASSIUM. PATHWAY : Glycolysis; final step. SUBUNIT : Homotetramer. ALTERNATIVE PRODUCTS : 2 isoforms; M1 (shown here) and M2 (AC P14786 ); are produced by alternative splicing. MISCELLANEOUS : THERE ARE 4 ISOZYMES OF PYRUVATE KINASE IN MAMMALS: L, R, M1 AND M2. L TYPE IS MAJOR ISOZYME IN THE LIVER, R IS FOUND IN RED CELLS, M1 IS THE MAIN FORM IN MUSCLE, HEART AND BRAIN, AND M2 IS FOUND IN EARLY FETAL TISSUES. SIMILARITY : BELONGS TO THE PYRUVATE KINASE FAMILY. |
|
27-Feb-03
Last Update 13-Mar-03