FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH KINASES. * SUBUNIT: Homodimer. * SUBCELLULAR LOCATION: Cytoplasmic. * TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES. * PTM: Phosphorylated by various PKC isozymes. * SIMILARITY: BELONGS TO THE 14-3-3 FAMILY. |
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13-DEC-02
Last Update 13-Mar-03