FUNCTION: CALCIUM/PHOSPHOLIPID-BINDING PROTEIN WHICH PROMOTES MEMBRANE FUSION AND IS INVOLVED IN EXOCYTOSIS. THIS PROTEIN REGULATES PHOSPHOLIPASE A2 ACTIVITY. IT SEEMS TO BIND FROM TWO TO FOUR CALCIUM IONS WITH HIGH AFFINITY. * SUBUNIT: IN PLACENTA 20% OF THE PROTEIN IS FOUND AS A COVALENTLY CROSS-LINKED DIMER WHICH IS GENERATED BY A TRANSGLUTAMINASE. * DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. * PTM: PHOSPHORYLATED BY PROTEIN KINASE C AND EPIDERMAL GROWTH FACTOR RECEPTOR/KINASE. PHOSPHORYLATION RESULTS IN LOSS OF THE INHIBITORY ACTIVITY. * SIMILARITY: BELONGS TO THE ANNEXIN FAMILY. * SIMILARITY: CONTAINS 4 ANNEXIN REPEATS. * DATABASE: NAME=Annexin I home page; WWW="http://www.mds.qmw.ac.uk/biopharm/annI.html". |
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27-DEC-02
Last Update 13-Mar-03