FUNCTION: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. * SUBUNIT: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity). * SUBCELLULAR LOCATION: Cytoplasmic. * MISCELLANEOUS: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. * MISCELLANEOUS: Irreversibly inactived by overoxidation of Cys-124 (to Cys-SO3H) upon oxidative stress. * SIMILARITY: BELONGS TO THE AHPC/TSA FAMILY. |
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04-JAN-03
Last Update 13-Mar-03