FUNCTION: IN ADDITION TO ITS ROLE AS A GLYCOLYTIC ENZYME, IT SEEMS THAT PGK-1 ACTS AS A POLYMERASE ALPHA COFACTOR PROTEIN (PRIMER RECOGNITION PROTEIN). * CATALYTIC ACTIVITY: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. * PATHWAY: Second phase of glycolysis; second step. * SUBUNIT: Monomer. * DISEASE: DEFECTS IN PGK1 ARE GENERALLY ASSOCIATED WITH CHRONIC HEMOLYTIC ANEMIA ALTHOUGH IT CAN BE ACCOMPANIED BY EITHER MENTAL RETARDATION OR MUSCULAR DISEASE (RHABDOMYOLYSIS). * SIMILARITY: BELONGS TO THE PHOSPHOGLYCERATE KINASE FAMILY. |
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07-NOV-00
Last Update 13-Mar-03