CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone phosphate. * PATHWAY: Plays an important role in several metabolic pathways. * SUBUNIT: Homodimer. * DISEASE: TPI DEFICIENCY IS THE MOST SEVERE CLINICAL DISORDER OF GLYCOLYSIS. IT IS ASSOCIATED WITH NEONATAL JAUNDICE, CHRONIC HEMOLYTIC ANEMIA, PROGRESSIVE NEUROMUSCULAR DYSFUNCTION, CARDIOMYOPATHY, AND INCREASED SUSCEPTIBILITY TO INFECTION. TPI DEFICIENCY IS AN AUTOSOMAL RECESSIVE DISORDER. * SIMILARITY: BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY. |
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16-JAN-03
Last Update 13-Mar-03