FUNCTION: INVOLVED IN STRESS RESISTANCE AND ACTIN ORGANIZATION. * SUBUNIT: Associates with alpha- and beta-tubulin and microtubules. * SUBCELLULAR LOCATION: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock. * INDUCTION: EXPRESSED IN RESPONSE TO ENVIRONMENTAL STRESSES SUCH AS HEAT SHOCK, OR ESTROGEN STIMULATION IN MCF-7 CELLS. * PTM: Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock. * SIMILARITY: BELONGS TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. |
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16-JAN-03
Last Update 13-Mar-03