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NiceProt View of Swiss-Prot: O00764

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name PDXK_HUMAN
Primary accession number O00764
Secondary accession number Q9BS02
Entered in Swiss-Prot in Release 35, November 1997
Sequence was last modified in Release 35, November 1997
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Pyridoxal kinase
Synonyms EC 2.7.1.35
Pyridoxine kinase
Gene name
PDXK or PKH or PNK
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID (ISOFORM 1).
MEDLINE=97256798; PubMed=9099727; [NCBI, ExPASy, EBI, Israel, Japan]
Hanna M.C., Turner A.J., Kirkness E.F.;
"Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor.";
J. Biol. Chem. 272:10756-10760(1997).
[2]
SEQUENCE FROM NUCLEIC ACID.
MEDLINE=20289799; PubMed=10830953; [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
[3]
SEQUENCE FROM NUCLEIC ACID (ISOFORMS 1 AND 2).
TISSUE=Eye, and Ovary;
Strausberg R.;
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
U89606; AAC51233.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP001752; BAA95540.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000123; AAH00123.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005825; AAH05825.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
Genew HGNC:8819; PDXK.
CleanEx HGNC:8819; PDXK.
MIM 179020 [NCBI / EBI].
GeneCards PDXK.
GeneLynx PDXK; Homo sapiens.
SOURCE PDXK; Homo sapiens.
Ensembl O00764; Homo sapiens. [Entry / Contig view]
InterPro IPR002173; PfkB.
IPR004625; Pyridox_kin.
Graphical view of domain structure.
Pfam PF00294; pfkB; 1.
TIGRFAMs TIGR00687; pyridox_kin; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O00764.
ProtoNet O00764.
ProtoMap O00764.
PRESAGE O00764.
DIP O00764.
ModBase O00764.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Transferase; Kinase; Alternative splicing.
Features
KeyFrom  To Length Description
VARSPLIC   83   110        MISSING (IN ISOFORM 2).
SEVIEWER logo Feature table viewer
Sequence information
Length: 312 AA Molecular weight: 35102 Da CRC64: 2DBDCAB5D8640569 [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA HWKGQVLNSD 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVLGDKW 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR KIHSQEEALR VMDMLHSMGP 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI 

       310 
         | 
EDPEIVVQAT VL 

O00764 in FASTA format

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