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[1]
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SEQUENCE FROM NUCLEIC ACID, PARTIAL SEQUENCE, AND CALCIUM-BINDING DATA.
TISSUE=Keratinocytes;
MEDLINE=98342150; PubMed=9675259; [NCBI, ExPASy, EBI, Israel, Japan]
Vorum H.,
Liu X.,
Madsen P.,
Rasmussen H.H.,
Honore B.;
"Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity.";
Biochim. Biophys. Acta 1386:121-131(1998).
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[2]
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SEQUENCE FROM NUCLEIC ACID.
MEDLINE=98260687; PubMed=9598325; [NCBI, ExPASy, EBI, Israel, Japan]
Yabe D.,
Taniwaki M.,
Nakamura T.,
Kanazawa N.,
Tashiro K.,
Honjo T.;
"Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.";
Genomics 49:331-333(1998).
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[3]
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SUBCELLULAR LOCATION.
MEDLINE=99240627; PubMed=10222138; [NCBI, ExPASy, EBI, Israel, Japan]
Vorum H.,
Hager H.,
Christensen B.M.,
Nielsen S.,
Honore B.;
"Human calumenin localizes to the secretory pathway and is secreted to the medium.";
Exp. Cell Res. 248:473-481(1999).
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- FUNCTION: NOT KNOWN, BINDS 7 CALCIUM IONS WITH A LOW AFFINITY.
- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen and secreted.
- TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
- SIMILARITY: BELONGS TO THE CREC FAMILY.
- SIMILARITY: Contains 7 EF-hand calcium-binding domains.
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This SWISS-PROT entry is copyright. It is produced through a collaboration
between the Swiss Institute of Bioinformatics and the EMBL outstation -
the European Bioinformatics Institute. There are no restrictions on its
use by non-profit institutions as long as its content is in no way
modified and this statement is not removed. Usage by and for commercial
entities requires a license agreement (See http://www.isb-sib.ch/announce/
or send an email to license@isb-sib.ch).
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| Length: 315 AA [This is the length of the unprocessed precursor] |
Molecular weight: 37107 Da [This is the MW of the unprocessed precursor] |
CRC64: 25BAE5A99B527375 [This is a checksum on the sequence] |
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10 20 30 40 50 60
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MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT
70 80 90 100 110 120
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FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE
130 140 150 160 170 180
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DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL
190 200 210 220 230 240
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HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF
250 260 270 280 290 300
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RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
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QATDFGEALV RHDEF
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O43852 in FASTA format |
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