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NiceProt View of Swiss-Prot: O75390
[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name CISY_HUMAN
Primary accession number O75390
Secondary accession numbers None
Entered in Swiss-Prot in Release 38, July 1999
Sequence was last modified in Release 38, July 1999
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Citrate synthase, mitochondrial [Precursor]
Synonym EC 4.1.3.7
Gene name
CS
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
 SEQUENCE FROM NUCLEIC ACID.
TISSUE=Heart;
MEDLINE=99026970; PubMed=9809442; [NCBI, ExPASy, EBI, Israel, Japan]
Goldenthal M.J., Marin-Garcia J., Ananthakrishnan R.;
"Cloning and molecular analysis of the human citrate synthase gene.";
Genome 41:733-738(1998).
Comments
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
AF047042; AAC25560.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
HSSP P00889; 2CTS. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
Genew HGNC:2422; CS.
CleanEx HGNC:2422; CS.
MIM 118950 [NCBI / EBI].
GeneCards CS.
GeneLynx CS; Homo sapiens.
SOURCE CS; Homo sapiens.
Ensembl O75390; Homo sapiens. [Entry / Contig view]
InterPro IPR002020; Citrate_synt.
Graphical view of domain structure.
Pfam PF00285; citrate_synt; 1.
PRINTS PR00143; CITRTSNTHASE.
PROSITE PS00480; CITRATE_SYNTHASE; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O75390.
ProtoNet O75390.
ProtoMap O75390.
PRESAGE O75390.
DIP O75390.
ModBase O75390.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Lyase; Tricarboxylic acid cycle; Mitochondrion; Transit peptide.
Features
KeyFrom   To Length Description
TRANSIT   1    27  27     MITOCHONDRION.
CHAIN   28   466  439     CITRATE SYNTHASE.
ACT_SITE   301   301        BY SIMILARITY.
ACT_SITE   347   347        BY SIMILARITY.
ACT_SITE   402   402        BY SIMILARITY.
SEVIEWER logo Feature table viewer
Sequence information
Length: 466 AA [This is the length of the unprocessed precursor] Molecular weight: 51706 Da [This is the MW of the unprocessed precursor] CRC64: 878841484BD7CC80 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MALLTAAARL LGTKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT FRQQHGKTVV 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE CQKLLPKAKG GEEPLPEGLF 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
WLLVTGCIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AVTALNSESN 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
FAQAYARGIS RTKYWELIYE DSVDLIAKLP CVAAKIYRNL YWEGSGIGAI DSNLDWSHNF 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
TNMLGYTDHQ FTELMRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL 

       310        320        330        340        350        360 
         |          |          |          |          |          | 
HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ 

       370        380        390        400        410        420 
         |          |          |          |          |          | 
REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY 

       430        440        450        460 
         |          |          |          | 
TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTEGLMKF VDSKSG
O75390 in FASTA format

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