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NiceProt View of Swiss-Prot: O75832

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name PSDA_HUMAN
Primary accession number O75832
Secondary accession numbers None
Entered in Swiss-Prot in Release 41, February 2003
Sequence was last modified in Release 41, February 2003
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name 26S proteasome non-ATPase regulatory subunit 10
Synonyms 26S proteasome regulatory subunit p28
Gankyrin
Gene name
PSMD10
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
SEQUENCE FROM NUCLEIC ACID.
MEDLINE=98382579; PubMed=9714768; [NCBI, ExPASy, EBI, Israel, Japan]
Hori T., Kato S., Saeki M., DeMartino G.N., Slaughter C.A., Takeuchi J., Toh-E A., Tanaka K.;
"cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.";
Gene 216:113-122(1998).
[2]
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Placenta;
Higashitsuji H., Fujita J.;
"Enhanced expression of a novel tumour marker in the human hepatomas.";
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[3]
SEQUENCE FROM NUCLEIC ACID.
Grafham D.;
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
[4]
SEQUENCE FROM NUCLEIC ACID.
TISSUE=Lung;
Strausberg R.;
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
  • SUBUNIT: Component of the PA700 complex.
  • SIMILARITY: Contains 5 ANK repeats.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
AB009619; BAA33215.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
D83197; BAA34594.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031177; CAA20117.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011960; AAH11960.1; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
Genew HGNC:9555; PSMD10.
CleanEx HGNC:9555; PSMD10.
MIM 603480 [NCBI / EBI].
GeneCards PSMD10.
GeneLynx PSMD10; Homo sapiens.
HSSP P42773; 1IHB. [HSSP ENTRY / PDB]
SOURCE PSMD10; Homo sapiens.
Ensembl O75832; Homo sapiens. [Entry / Contig view]
InterPro IPR002110; ANK.
Graphical view of domain structure.
Pfam PF00023; ank; 5.
PRINTS PR01415; ANKYRIN.
SMART SM00248; ANK; 5.
PROSITE PS50088; ANK_REPEAT; 5.
PS50297; ANK_REP_REGION; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS O75832.
ProtoNet O75832.
ProtoMap O75832.
PRESAGE O75832.
DIP O75832.
ModBase O75832.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Proteasome; ANK repeat; Repeat.
Features
KeyFrom   To Length Description
REPEAT   39    68  30     ANK 1.
REPEAT   72   101  30     ANK 2.
REPEAT   105   134  30     ANK 3.
REPEAT   138   167  30     ANK 4.
REPEAT   171   200  30     ANK 5.
FT aligner logo Feature aligner
SEVIEWER logo Feature table viewer
Sequence information
Length: 226 AA Molecular weight: 24428 Da CRC64: 57158E33146EC7C8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC 

       190        200        210        220 
         |          |          |          | 
DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG 

O75832 in FASTA format

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