FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. * SUBUNIT: Homohexamer. * ALTERNATIVE PRODUCTS: 2 isoforms; 1 (shown here) and 2; may be produced by alternative splicing. * DISEASE: SERA FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS OFTEN CONTAIN ANTIBODIES THAT REACT WITH THE KI ANTIGEN. * SIMILARITY: BELONGS TO THE PA28 FAMILY. |
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04-JAN-03
Last Update 13-Mar-03