FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH KINASES. ACTIVATES THE ADP-RIBOSYLTRANSFERASE (EXOS) ACTIVITY OF BACTERIAL ORIGIN. * SUBUNIT: Homodimer. * SUBCELLULAR LOCATION: Cytoplasmic. * TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES. * PTM: ISOFORM DELTA DIFFERS FROM ISOFORM ZETA IN BEING PHOSPHORYLATED (BY SIMILARITY). * SIMILARITY: BELONGS TO THE 14-3-3 FAMILY. * CAUTION: WAS ORIGINALLY (REF.1) THOUGHT TO HAVE PHOSPHOLIPASE A2 ACTIVITY. |
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22-SEP-00
Last Update 13-Mar-03