Publications｜細胞情報科学分野
2000年以降の主要業績
論文・総説等（英文）
Yoshida H, Yokota S, Satoh K, Ishisaki A, Chosa N.
"Connective tissue growth factor enhances TGF-β1-induced osteogenic differentiation via activation of p38 MAPK in mesenchymal stem cells".
Journal of Oral Biosciences, 66:68-75, 2024.
[PubMed]
[FullText]
Obara N, Kyakumoto S, Yamaguchi S, Yamada H, Ishisaki A, Kamo M.
"Disruption of CADM1-dependent cell-cell adhesion in human oral squamous cell carcinoma cells results in tumor progression, possibly through an increase of MMP-2 and MMP-9 expression".
Journal of Oral Biosciences, 66:151-159, 2024.
[PubMed]
[FullText]
Asanuma K, Yokota S, Chosa N, Kamo M, Ibi M, Mayama H, Irie T, Satoh K, Ishisaki A.
"Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint".
Journal of Oral Biosciences, 65:97-103, 2023.
[PubMed]
[FullText]
Yokota S, Chosa N, Matsumoto S, Satoh K, Ishisaki A.
"Extracellular adenosine 5'-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocyte".
Molecular Biology Reports, 50:1595-1602, 2023.
[PubMed]
[FullText]
Miyamae Y, Ohta M, Sato K, Ishisaki A, Chosa N.
"TGF-β1-induced IL-6 expression via MEK pathway in mesenchymeal stem cells enhances NGF-dependent neurite extension in PC12 cells".
Dental Journal of Iwate Medical University, 47:19-33, 2022.
[J-STAGE]
[FullText]
Ishikawa Y, Hirano T, Yamada H, Ishisaki A, Kamo M.
"Sclerostin derived from EMT-promoted human oral squamous cell carcinoma cells induces IL-6-, and IL-17A-mediated M1 to M2 polarization shift in THP-1-derived macrophages".
Dental Journal of Iwate Medical University, 47:34-50, 2022.
[J-STAGE]
[FullText]
Koizumi R, Kuroshima S, Kaneko H, Sasaki M, Ishisaki A, Sawase T.
"Zoledronic acid deteriorates soft and hard tissue healing of murine tooth extraction sockets in a dose-dependent manner".
Calcified Tissue International, 110:104-116, 2022.
[PubMed]
[FullText]
Takeda K, Ishikawa Y, Yamada H, Ishisaki A, Kamo M.
"CCL20 derived from PMA-differentiated macrophages abrogates TGF-β1-induced expression of cancer progression suppressor CXCL14 in HSC-4 cells PI3K-, MEK1/2-, and NF-κB-dependent manners".
Dental Journal of Iwate Medical University, 46:19-32, 2021.
[J-STAGE]
[FullText]
Tamaki S, Kuroshima S, Hayano H, Nakajima K, Kakehashi H, Ishisaki A, Sawase T.
"Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice".
Bone, 141:115560, 2020.
[PubMed]
[FullText]
Hirano T, Saito D, Yamada H, Ishisaki A, Kamo M.
"TGF-β1 induces N-cadherin expression by upregulating Sox9 expression and promoting its nuclear translocation in human oral squamous cell carcinoma cells".
Oncology Letters, 20:474-482, 2020.
[PubMed]
[FullText]
Hirano T, Saito D, Komatsu Y, Yamada H, Ishisaki A, Kamo M.
"YAP/TAZ activation, induced by disruption of E-cadherin-mediated cell-to-cell contact, promotes the cadherin switch by facilitating nuclear translocation of Slug in human oral squamous cell carcinoma HSC-4 cells".
Dental Journal of Iwate Medical University, 45:23-34, 2020.
[J-STAGE]
[FullText]
Matsumoto S, Yokota S, Chosa N, Kyakumoto S, Kimura H, Kamo M, Satoh K, Ishisaki A.
"Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular-joint-derived fibroblast-like synoviocytes via mitogen-activated protein kinase kinase/extracellular signal-regulated kinase".
Experimental and Therapeutic Medicine, 20:1967-1974, 2020.
[PubMed]
[FullText]
Matsumoto S, Yokota S, Kyakumoto S, Chosa N, Satoh K.
"Adenosine 5'-triphosphate strengthens receptor tyrosine kinase-mediated suppression of fibrogenic activity in fibroblast-like synoviocytes derived from mouse temporomandibular joints possibly through P2Y2, P2Y4, and P2Y13 purinergic receptors".
Dental Journal of Iwate Medical University, 45: 46-57, 2020.
[J-STAGE]
[FullText]
Hayano H, Kuroshima S, Sasaki M, Tamaki S, Inoue M, Ishisaki A, and Sawase T.
"Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice".
Bone, 135:115308, 2020.
[PubMed]
[FullText]
Ohta M., Chosa N., Kyakumoto S., Yokota S., Okubo N., Nemoto A., Kamo M., Joh S., Satoh K., Ishisaki A.
"IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals".
International Journal of Molecular Medicine, 43:1484-1494, 2018.
[PubMed]
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Ibi M., Horie S., Kyakumoto S., Chosa N., Yoshida M., Kamo M., Ohtsuka M., Ishisaki A.
"Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint".
Bioscience Reports, 38:BSR20171217, 2018.
[PubMed]
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Ohta M.*, Nemoto A.*, Chosa N., Kyakumoto S., Yokota S., Kamo M., Shibata S., Joh S., Satoh K., Ishisaki A.
"Toll-like receptor 4-mediated signaling activated by lipopolysaccharide suppresses transforming growth factor-beta-induced nerve growth factor expression in periodontal ligament-derived fibroblasts".
Dental Journal of Iwate Medical University, 43:61-73, 2018. *co-first authors.
[J-STAGE]
[PDF]
Chosa N., Ishisaki A.
"Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin".
Japanese Dental Science Review, 54:37-44, 2018.
[PubMed]
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Nemoto A., Chosa N., Kyakumoto S., Yokota S., Kamo M., Noda M., Ishisaki A.
"Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells".
Molecular Medicine Reports, 17:3448-3454, 2018.
[PubMed]
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Takizawa N.*, Okubo N.*, Kamo M., Chosa N., Mikami T., Suzuki K., Yokota S., Ibi M., Ohtsuka M., Taira M., Yaegashi T., Ishisaki A., Kyakumoto S.
"Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture".
Experimental Cell Research, 358:411-420, 2017. *co-first authors.
[PubMed]
[FullText]
[PDF]
[Mesenchymal Cell News]
Kanno Y., Maruyama C., Matsuda A., Ishisaki A.
"uPA-derived peptide, A6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss".
Immunity, Inflammation and Disease, 5:289-299, 2017.
[PubMed]
[FullText]
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Kanno Y., Ishisaki A., Kuretake H., Maruyama C., Matsuda A., Matsuo O.
"Alpha2-antiplasmin modulates bone formation by negatively regulating the osteoblast differentiation and its function".
International Journal of Molecular Medicine, 40:854-858, 2017.
[PubMed]
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Inoue M., Yamada J, Aomatsu-Kikuchi E., Satoh K., Kondo H., Ishisaki A., Chosa N.
"SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells".
Molecular Medicine Reports, 15:4069-4076, 2017.
[PubMed]
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Inoue M., Ohtsu K., Ohtsuka M., Takafuji K., Harada H., Ishisaki A., Kondo H.
"Healing mechanism surrounding transplanted bone using transgenic mice expressing red fluorescent protein in vivo".
Journal of Oral Tissue Engineering, 14:74-85, 2017.
[J-STAGE]
[PDF]
Yokota S., Chosa N., Kyakumoto S., Kimura H., Ibi M., Kamo M., Satoh K., Ishisaki A.
"ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint".
International Journal of Molecular Medicine, 39:799-808, 2017.
[PubMed]
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Suzuki K.*, Chosa N.*, Sawada S., Takizawa N., Yaegashi T., Ishisaki A.
"Enhancement of anti-inflammatory and osteogenic abilities of mesenchymal stem cells via cell-to-cell adhesion to periodontal ligament-derived fibroblasts".
Stem Cells International, 2017:3296498, 2017. *co-first authors.
[PubMed]
[FullText]
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Chiba T., Ishisaki A., Kyakumoto S., Shibata T., Yamada H., Kamo M.
"Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression".
Oncology Reports, 37:713-720, 2017.
[PubMed]
[FullText]
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Bologna-Molina R., Takeda Y., Kuga T., Chosa N., Kitagawa M., Takata T., Ishisaki A., Mikami T.
"Expression of Wilms' tumor 1 (WT1) in ameloblastomas".
Journal of Oral Science, 58:407-413, 2016.
[PubMed]
[FullText]
[PDF]
Kanno Y., Ishisaki A., Miyashita M., and Matsuo O.
"The blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathway".
Immunity, Inflammation and Disease, 4:338-349, 2016.
[PubMed]
[FullText]
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Komatsu Y., Ibi M., Chosa N., Kyakumoto S., Kamo M., Shibata T., Sugiyama Y., Ishisaki A.
"Zoledronic acid suppresses transforming growth factor-β (TGF-β)-induced fibrogenesis by human gingival fibroblasts possibly through down-regulation of TGF-β type I receptor expression".
International Journal of Molecular Medicine, 38:139-147, 2016.
[PubMed]
[FullText]
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Hino M., Kamo M., Saito D., Kyakumoto S., Shibata T., Mizuki H., Ishisaki A.
"Transforming growth factor-β1 induces invasion ability of HSC-4 human squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signaling axis".
Journal of Biochemistry, 159:631-640, 2016.
[PubMed]
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Igarashi Y.*, Chosa N.*, Sawada S., Kondo H., Yaegashi T., Ishisaki A.
"VEGF-C and TGF-β reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes".
International Journal of Molecular Medicine, 37:1005-1013, 2016. *co-first authors.
[PubMed]
[FullText]
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Sawada S.*, Chosa N.*, Takizawa N., Yokota J., Igarashi Y., Tomoda K., Kondo H., Yaegashi T., Ishisaki A.
"Establishment of mesenchymal stem cell lines derived from the bone marrow of GFP-transgenic mice exhibiting diversity in intracellular TGF-β and BMP signaling".
Molecular Medicine Reports, 13:2023-2031, 2016. *co-first authors.
[PubMed]
[FullText]
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Kanno Y., Ishisaki A., Kawashita E., Kuretake H., Ikeda K., Matstuo O.
"uPA attenuated LPS-induced inflammatory osteoclastogenesis through the plasmin/PAR-1/Ca2+/CaMKK/AMPK axis".
International Journal of Biological Sciences, 12:63-71, 2016.
[PubMed]
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Furukawa S.*, Kuwajima Y.*, Chosa N., Satoh K., Ohtsuka M., Miura H., Kimura M., Inoko H., Ishisaki A., Fujimura A., Miura H.
"Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice".
Experimental and Therapeutic Medicine, 10:1380-1386, 2015. *co-first authors.
[PubMed]
[FullText]
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Akazawa Y., Hasegawa T., Yoshimura Y., Chosa N., Asakawa T., Ueda K., Sugimoto A., Kitamura T., Nakagawa H., Ishisaki A., Iwamoto T.
"Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth".
International Journal of Molecular Medicine, 36:442-448, 2015.
[PubMed]
[FullText]
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Kuramitsu-Fujimoto S., Saito N., Ariyoshi W., Okinaga T., Kamo M., Ishisaki A., Takata T., Yamaguchi K., and Nishihara T.
"Novel biological activity of ameloblastin in enamel matrix derivative".
Journal of Applied Oral Science, 23:49-55, 2015.
[PubMed]
[FullText]
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Nakajima K., Itoh F., Nakamura M., Kawamura A., Yamazaki T., Kozakai T., Takusari M., Ishisaki A.
"Opposing effects of lactoferrin on the proliferation of fibroblasts and epithelial cells from bovine mammary gland".
Journal of Dairy Science, 98:1069-1077, 2015.
[PubMed]
Taira M., Hatakeyama W., Yokota J., Chosa N., Ishisaki A., Takafuji K., Kihara H., Kondo H., Hattori M.
"Tracking GFP-labeled transplanted mouse MSC in nude mice using in vivo fluorescence imaging".
Nano Biomedicine, 6:73-77, 2014.
[J-STAGE]
[PDF]
Tamaoki N., Takahashi K., Aoki H., Iida K., Kawaguchi T., Hatakeyama D., Inden M., Chosa N., Ishisaki A., Kunisada T., Shibata T., Goshima N., Yamanaka S., Tezuka K.
"The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells".
Scientific Reports, 4:7283, 2014.
[PubMed]
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[ESC & iPSC News]
Asano T., Taoka M., Yamauchi Y., Everroad C.R., Seto Y., Isobe T., Kamo M., Chosa N.
"Re-examination of a α-chymotrypsin-solubilized laccase in the pupal cuticle of the silkworm, Bombyx mori: insights into the regulation system for laccase activation during the ecdysis process".
Insect Biochemistry and Molecular Biology, 55:61-69, 2014.
[PubMed]
Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N.
"Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells".
Scientific Reports, 4:3652, 2014.
[PubMed]
[FullText]
[PDF]
[Faculty of 1000]
[Mesenchymal Cell News]
Matsui M., Chosa N., Shimoyama Y., Minami K., Kimura S., Kishi M.
"Effects of tongue cleaning on bacterial flora in tongue coating and dental plaque: A crossover study".
BMC Oral Health, 14:4, 2014.
[PubMed]
[FullText]
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Aomatsu E.*, Chosa N.*, Nishihira S., Sugiyama Y., Miura H., Ishisaki A.
"Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRβ in a ligand-independent manner in mesenchymal stem cells".
International Journal of Molecular Medicine, 33:565-572, 2014. *co-first authors.
[PubMed]
[FullText]
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Yokota J., Chosa N., Sawada S., Okubo N., Takahashi N., Hasegawa T., Kondo H., Ishisaki A.
"PDGF-induced PI3K-mediated signal enhances TGF-β-induced osteogenic differentiation of human mesenchymal stem cells in the TGF-β-activated MEK-dependent manner".
International Journal of Molecular Medicine, 33:534-542, 2014.
[PubMed]
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Kimura H.*, Okubo N.*, Chosa N., Kyakumoto S., Kamo M., Miura H., Ishisaki A.
"EGF positively regulates the proliferation and migration, and negatively regulates the myofibroblast differentiation of periodontal ligament-derived endothelial progenitor cells through MEK/ERK- and JNK-dependent signals".
Cellular Physiology and Biochemistry, 32:899-914, 2013. *co-first authors.
[PubMed]
[FullText]
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Hatakeyama W., Taira M., Chosa N., Kihara H., Ishisaki A., Kondo H.
"Effects of apatite particle size contained in two apatite/collagen composites on osteogenic differentiation profile in osteoblastic cells".
International Journal of Molecular Medicine, 32:1255-1261, 2013.
[PubMed]
[FullText]
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Sawada S., Chosa N., Ishisaki A., Naruishi K.
"Enhancement of gingival inflammation induced by synergism of IL-1β and IL-6".
Biomedical Research, 43:31-40, 2013.
[PubMed] [PDF]
Takizawa N., Sawada S., Chosa N., Ishisaki A., Naruishi K.
"Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts".
Biomedical Research, 43:1-11, 2013.
[PubMed] [PDF]
Saito D., Kyakumoto S., Chosa N., Ibi M., Takahashi N., Okubo N., Sawada S., Ishisaki A., Kamo M.
"Transforming growth factor-β1 induces epithelial-mesenchymal transition and integrin α3β1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug".
Journal of Biochemistry, 153:303-315, 2013.
[PubMed] [PDF]
Mikami T., Hada T., Chosa N., Ishisaki A., Mizuki H., Takeda Y.
"Expression of WT1 (Wilms’ tumor 1) in oral squamous cell carcinoma".
Journal of Oral Pathology and Medicine, 42:133-139, 2013.
[PubMed] [PDF]
Yoshida M.*, Okubo N.*, Chosa N., Hasegawa T., Ibi M., Kamo M., Kyakumoto S., Ishisaki A.
"TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals".
International Journal of Biological Sciences, 8:1062-1074, 2012. *co-first authors.
[PubMed] [PDF] [GlobalMedicalDiscovery]
Shenton M.R., Berberich T., Kamo M., Yamashita T., Taira H., Terauchi R.
"Use of intercellular washing fluid to investigate the secreted proteome of the rice-Magnaporthe interaction".
Journal of Plant Research, 125:311-316, 2012.
[PubMed] [PDF]
Inoko A., Matsuyama M., Goto H., Ohmuro-Matsuyama Y., Hayashi Y., Enomoto M., Ibi M., Urano T., Yonemura S., Kiyono T., Izawa I., Inagaki M.
"Trichoplein and Aurora A block aberrant primary clia assembly in proliferating cells".
Journal of Cell Biology, 197:391-405, 2012.
[PubMed] [PDF]
Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Fujihara Y., Kitamura T., Tanaka M., Ishisaki A., Mitome M.
"Differential effects of TGF-β1 and FGF-2 on SDF-1α expression in human periodontal ligament cells derived from deciduous teeth in vitro".
International Journal of Molecular Medicine, 30:35-40, 2012.
[PubMed] [PDF]
Asakawa T., Chosa N., Yoshimura Y., Asakawa A., Tanaka M., Ishisaki A., Mitome M., Hasegawa T.
"Fibroblast growth factor 2 inhibits the expression of stromal
cell-derived factor 1α in periodontal ligament cells derived from human permanent teeth in vitro".
International Journal of Molecular Medicine, 29:569-573, 2012.
[PubMed] [PDF]
Takahashi M., Okubo N., Chosa N., Takahashi N., Ibi M., Kamo M., Mizuki H., Ishisaki A., Kyakumoto S.
"Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells".
International Journal of Molecular Medicine, 29:357-364, 2012.
[PubMed] [PDF]
Takahashi N., Chosa N., Hasegawa T., Nishihira S., Okubo N., Takahashi M., Sugiyama Y., Tanaka M., Ishisaki A.
"Dental pulp cells derived from permanent teeth express higher levels of R-cadherin than do deciduous teeth: Implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells".
Archives of Oral Biology, 57:44-51, 2012.
[PubMed] [PDF]
Nakajima K., Kanno Y., Nakamura M., Gao X-D., Kawamura A., Itoh F., Ishisaki, A.
"Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway".
Biometals, 24:847-856, 2011.
[PubMed] [PDF]
Kanno Y., Ishisaki A., Kawashita E., Chosa N., Nakajima K., Nishihara T., Toyoshima K., Okada K., Ueshima S., Matsushita K., Matsuo O., Matsuno H.
"Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function".
Journal of Biological Chemistry, 286:8952-8960, 2011.
[PubMed] [PDF]
Nishihira S., Okubo N., Takahashi N., Ishisaki A., Sugiyama Y., Chosa N.
"High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells".
Cell Biology International, 35:475-481, 2011.
[PubMed] [PDF]
Ibi M.*, Zou P.*, Inoko A.*, Shiromizu T., Matsuyama M., Hayashi Y., Enomoto M., Mori D., Hirotsune S., Kiyono T., Tsukita S., Goto H., Inagaki M.
"Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein".
Journal of Cell Science, 124:857-864, 2011. *co-first authors.
[PubMed] [PDF]
Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Ishisaki A., Tanaka M.
"Establishment of immortalized human periodontal ligament cells derived from deciduous teeth".
International Journal of Molecular Medicine, 26:701-705, 2010.
[PubMed] [PDF]
Yoshida Y., Ito S., Kamo M., Kezuka Y., Tamura H., Kunimatsu K., Kato H.
"Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in
Fusobacterium nucleatum subsp. nucleatum ATCC 25586".
Microbiology, 156:2260-2269, 2010.
[PubMed] [PDF]
Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Asakawa A., Ishisaki A., Tanaka M.
"Effect of fibroblast growth factor-2 on periodontal ligament cells derived from human deciduous teeth in vitro".
Experimental and Therapeutic Medicine, 3:337-341, 2010.
[PubMed] [PDF]
Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Asakawa A., Ishisaki A., Tanaka M.
"Effect of fibroblast growth factor-2 on dental pulp cells derived from human deciduous teeth in vitro".
Experimental and Therapeutic Medicine, 1:477-480, 2010.
[PDF]
Okubo N., Ishisaki A., Iizuka T., Tamura M., Kitagawa Y.
"Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive
blood vessel structures in a PI3K-activation-dependent manner".
Journal of Vascular Research, 47:369-383, 2010.
[PubMed] [PDF]
Nakajima K., Nakamura M., Ishisaki A., Kozakai T.
"Synergistic effect of dexamethasone and prolactin on VEGF expression bovine mammary epithelial cells via p44/p42 MAP kinase".
Asian-Australasian Journal of Animal Sciences, 22:788-795, 2009.
[PDF]
Shirai K., Ishisaki A., Kaku T., Tamura M., Furuichi Y.
"Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein".
Journal of Periodontal Research, 44:238-247, 2009.
[PubMed] [PDF]
Minami A., Fujiwara M., Furuto A., Fukao Y., Yamashita T., Kamo M., Kawamura Y., Uemura M.
"Alterations in Detergent-Resistant Plasma Membrane Microdomains in Arabidopsis thaliana During Cold Acclimation".
Plant and Cell Physiology, 50:341-359, 2009.
[PubMed] [PDF]
Ohta M., Sugano A., Goto S., Yusoff S., Hirota Y., Funakoshi K., Miura K., Maeda E., Takaoka N., Sato N., Ishizuka H.,
Arizono N., Nishio H., Takaoka Y.
"Full-length sequence of mouse acupuncture-induced 1-L (Aig1l) gene including its transcriptional start site".
Evidence-based complementary and alternative medicine : eCAM, Epub ahead of print, 2009.
[PubMed] [PDF]
Taira M., Chosa N., Sasaki K., SaitohS., Nezu T., Sato N., Araki Y.
"Gene expression analyses of human mesenchymal stem cells cultured in osteogenic differentiation medium for 3, 7, 14 and 21 days by genome focus DNA microarray and real-time PCR".
Journal of Oral Tissue Engineering, 5:35-47, 2007.
[J-STAGE] [PDF]
Takaoka Y.*, Ohta M.*, Ito A., Takamatsu K., Sugano A., Funakoshi K., Takaoka N., Sato N., Arizono N., Goto S., Maeda E.
"Electroacupuncture suppresses myostatin gene expression: cell proliferation reaction in mouse skeletal muscle".
Physiological Genomics, 30:102-110, 2007. *co-first authors.
[PubMed] [PDF]
Jang I.H.*, Chosa N.*, Kim S.H., Nam H.J., Lemaitre B., Ochiai M., Kambris Z., Brun S., Hashimoto C., Ashida M., Brey P.T., Lee W.J.
"A Spatzle-processing enzyme is indispensable for Toll signaling activation in Drosophila innate immunity".
Developmental Cell, 10:45-55, 2006. *co-first authors.
[PubMed] [PDF]
Taira M., Chosa N., Sasaki K., Saitoh S., Nezu T., Sato N., Araki Y.
"DNA microarray analyses of gene expression in human mesenchymal stem cells cultured in osteogenic differentiation medium for 14 days".
Journal of Oral Tissue Engineering, 3:25-53, 2005.
[J-STAGE] [PDF]
Iida T., Kamo M., Uozumi N., Inui T., Imai K.
"Further application of a two-step heparin affinity chromatography method using divalent cations as eluents:
purification and identification of membrane-bound heparin binding proteins from the mitochondrial fraction of HL-60 cells".
Journal of Chromatography B, 823:209-212. 2005.
[PubMed]
Chosa N.*, Kyakumoto S.*, Kito N., Kamo M., Sato N.
"Mechanism of Fas-mediated cell death and its enhancement by TNF-α in human salivary gland adenocarcinoma cell line HSG".
European Journal of Oral Science, 112:338-346, 2004. *co-first authors.
[PubMed] [PDF]
Chosa N.*, Taira M.*, Saitoh S., Sato N., Araki Y.
"Characterization of apatite formed on alkaline-heat-treated Ti".
Journal of Dental Research, 83:465-469, 2004. *co-first authors.
[PubMed] [PDF]
Taira M., Chosa N., Saitoh S., Sasaki K., Sato N., Takahashi J., Araki Y.
"Effects of the medium type, serum amount and dexamethasone induction on the cell proliferation and alkaline phosphatase activity of twice-passaged SD rats' bone marrow stromal cells".
Journal of Oral Tissue Engineering, 1:59-68, 2004.
[J-STAGE] [PDF]
Takaoka Y., Ohta M., Miyakawa K., Nakamura O., Suzuki M., Takahashi K., Yamamura K., Sakaki Y.
"Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met".
American Journal of Pathology, 164:337-345, 2004.
[PubMed] [PDF]
Kyakumoto S., Kito N., Sato N.
"Expression of cAMP response element binding protein (CREB)-binding protein (CBP) and the implication in retinoic acid-inducible transcription activation in human salivary gland adenocarcinoma cell line HSG".
Endocrine Research, 29:277-289, 2003.
[PubMed]
Tsugita A., Miyazaki K., Nabetani T., Nozawa T., Kamo M., Kawakami T.
"Application of chemical selective cleavage methods to analyze post-translational modification in proteins".
Proteomics, 1:1082-1091, 2001.
[PubMed]
Seo D., Tomioka A., Kusumoto N., Kamo M., Enami I., Sakurai H.
"Purification of ferredoxins and their reaction with purified reaction center complex from the green sulfur bacterium Chlorobium tepidum".
Biochimica et Biophysica Acta, 1503:377-384, 2001.
[PubMed]
Araki N., Morimasa T., Sakai T., Tokuoh H., Yunoue S., Kamo M., Miyazaki K., Abe K., Saya H., Tsugita A.
"Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis".
Electrophoresis, 21:1880-1889, 2000.
[PubMed]
Tsugita A., Kawakami T., Uchida T., Sakai T., Kamo M., Matsui T., Watanabe Y., Morimasa T., Hosokawa K., Toda T.
"Proteome analysis of mouse brain: two-dimensional electrophoresis profiles of tissue proteins during the course of aging".
Electrophoresis, 21:1853-1871, 2000.
[PubMed]
Nagai M., Kyakumoto S., Sato N.
"Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation".
Biochemical and Biophysical Research Communications, 269:532-536, 2000.
[PubMed]
論文・総説等（和文）
相原恵子.
"SCRG1はマクロファージ様細胞Raw264.7におけるCCR7の発現を増強することでCCL19への走化性を誘導する". 岩手医科大学歯学雑誌, 45:35-45, 2020.
[FullText]
加茂政晴, 齋藤大嗣, 樋野雅文, 千葉高大, 山田浩之, 石崎明.
"ヒト口腔扁平上皮癌細胞HSC-4における細胞遊走・浸潤能に関与するTGF-β1誘導性上皮間葉転換の分子機構（総説）". 岩手医科大学歯学雑誌, 43:107-121, 2018.
[FullText]
[PDF]
石崎明, 客本齊子, 横田聖司, 加茂政晴, 帖佐直幸.
"間葉系幹細胞を利用した再生医療における新たな戦略（総説）". お茶の水醫學雑誌, 66:247-258, 2018.
[FullText]
[PDF]
石崎明, 帖佐直幸.
"間葉系幹細胞の幹細胞性の維持に働く新たな分子機構（みにれびゅう）". 生化学, 89:428-431, 2017.
[FullText]
[PDF]
帖佐直幸, 菊池-青松恵美子, 西平宗功, 横田潤, 高橋典子, 近藤尚知, 杉山芳樹, 三浦廣行, 石崎明.
"間葉系幹細胞のstemnessを維持するシグナル伝達経路（総説）". 岩手医科大学歯学雑誌, 39:56-65, 2014. [PDF]
桑島幸紀, 大塚正人, 石崎明, 藤村朗.
"赤色蛍光強発現遺伝子導入マウスにおける蛍光発現部位の形態学的検討". 岩手医科大学歯学雑誌, 37:24-37, 2012. [PDF]
帖佐直幸, 石崎明. "骨における血管新生と線溶系（総説）". 日本血栓止血学会誌, 20:12-17, 2009.
[J-STAGE] [PDF]
小川恵子, 加茂政晴, 水城春美, 客本斉子.
"Mycoplasma salivariumにおけるヌクレアーゼの存在とその特性". 岩手医科大学歯学雑誌, 33:109-122, 2008. [PDF]
平雅之, 荒木吉馬, 帖佐直幸, 佐藤詔子. "アパタイトの骨再生作用（総説）". セラミックス, 43:290-293, 2008.
鎌田仁, 加茂政晴, 客本斉子.
"Galectin-1はヒト口腔扁平上皮癌細胞のアノイキスを抑制する". 岩手医科大学歯学雑誌, 32:157-169, 2007. [PDF]
加茂政晴, 客本斉子, 佐藤詔子. "ヒト顎下腺由来腺癌細胞株のプロテオミクス（総説）".
口腔組織培養学会誌, 15:11-28, 2006.
南順子, 客本斉子, 加茂政晴. "コラーゲンスポンジを用いた三次元培養におけるヒト顎下腺由来腺癌細胞株の遺伝子発現".
岩手医科大学歯学雑誌, 30:216-227, 2005. [PDF]
鬼頭典子, 客本斉子, 帖佐直幸. "ヒト顎下腺由来腺癌細胞株 (HSG) における抗Fas抗体誘導アポトーシスシグナルへのHSP90の関与".
Journal of Oral Biosciences, 46:229-242, 2004.
[J-STAGE] [PDF]
加茂政晴, 客本斉子, 帖佐直幸, 佐藤詔子. "プロテオーム解析によるヒト顎下腺由来腺癌細胞株とその派生細胞株における発現タンパク質の比較".
口腔組織培養学会誌, 9:31-42, 2000.
著書・教科書等
Okubo N., Ishisaki A.
"Angiogenic capacity of periodontal ligament-derived stem cells".
[Advances in oral tissue engineering. Murata M. & Um IW. (ed.)] Quintessence Publishing, pp9-14, 2014.
[Publisher]
[Amazon]
Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Ishisaki A., Tanaka M.
"Eatablishment of periodontal ligament cell line derived from human deciduous teeth".
[Interface oral health science 2011. Sasaki, K. (ed.)] Springer, New York, pp114-116, 2012.
[Publisher]
[Amazon]
Asakawa T., Chosa N., Hasegawa T., Asakawa A., Ishisaki A., Tanaka M.
"Regulation of SDF-1 expression in periodontal ligament cells derived from human permanent teeth".
[Interface oral health science 2011. Sasaki, K. (ed.)] Springer, New York, pp107-109, 2012.
[Publisher]
[Amazon]
石崎明: [早川太郎, 須田立雄, 木崎治俊 監修. "口腔生化学 (第5版)".] 医歯薬出版株式会社. 2011.
[Publisher]
[Amazon]
受賞・招待講演等
菊池-青松恵美子: [Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N.
"Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2014.
石崎明.
"スフェロイド培養法を用いた歯周靭帯由来細胞による血管組織形成の試み".
第50回日本口腔組織培養学会, 招待講演, 2013.
吉田茉莉子: [Yoshida M., Okubo N., Chosa N., Hasegawa T., Ibi M., Kamo M., Kyakumoto S., Ishisaki A.
"TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2013.
澤田俊輔: [Sawada S., Chosa N., Ishisaki A., Naruishi K.
"Enhancement of gingival inflammation induced by synergism of IL-1β and IL-6".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2013.
石崎明.
"細胞増殖因子による間葉系幹細胞/前駆細胞の増殖・分化調節を基盤とした新たな再生医療樹立の試み".
第31回消化器病態生理勉強会, 招待講演, 2012.
高橋美香子: [Takahashi M., Okubo N., Chosa N., Takahashi N., Ibi M., Kamo M., Mizuki H., Ishisaki A., Kyakumoto S.
"Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2012.
西平宗功: [Nishihira S., Okubo N., Takahashi N., Ishisaki A., Sugiyama Y., Chosa N.
"High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2012.
石崎明.
"Elucidation of the molecular mechanisms underlying the ligand-controlled growth and differentiation of mesenchymal stem/progenitor cells: study on the establishment of novel cell therapy for construction of a vascular system".
第37回日本微小循環学会総会, シンポジスト, 2012.
大久保直登.
"歯根膜由来幹細胞による血管内皮細胞マーカー陽性血管構造の構築".
北海道歯学会, 北海道歯学会賞, 2011.
石崎明.
"未分化間葉系細胞の増殖・分化制御メカニズムの解明 ―歯周靱帯再生医療の実現を目指して―".
口腔先端応用医科学研究会, 招待講演, 2011.
大久保直登, 石崎明.
"ラット歯根膜由来未分化間葉系細胞による血管様構造物の形成".
岩手医科大学歯学会, 優秀発表賞, 2010.
大久保直登, 田村正人, 北川善政, 加茂政晴, 客本斉子, 帖佐直幸, 高橋典子, 飯塚正, 石崎明.
"ラット歯根膜由来間葉系幹細胞様細胞によるPI3K/Akt依存的なTie-2陽性血管構造の形成".
口腔先端応用医科学研究会, 再生補綴医学会若手賞ファイナリスト, 2009.
白井要: [Shirai K., Ishisaki A., Kaku T., Tamura M., Furuichi Y.
"Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein".]
日本歯周病学会, 奨励賞, 2009.
石崎明, 帖佐直幸.
"FGFとTGF-βスーパーファミリーの相互作用による未分化間葉系細胞の細胞増殖・分化制御機構の解明".
口腔医科学フロンティア学術集会, 招待講演, 2009.
大久保直登, 田村正人, 飯塚正, 加茂政晴, 客本斉子, 帖佐直幸, 高橋典子, 北川善政, 石崎明.
"歯根膜由来幹細胞による血管内皮細胞マーカー陽性血管構造の形成".
硬組織再生生物学会, 優秀ポスター賞, 2008.
小川恵子: [小川恵子, 加茂政晴, 水城春美, 客本斉子.
"Mycoplasma salivariumにおけるヌクレアーゼの存在とその特性".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2008.
鎌田仁: [鎌田仁, 加茂政晴, 客本斉子.
"Galectin-1はヒト口腔扁平上皮癌細胞のアノイキスを抑制する".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2007.
佐藤詔子.
日本口腔組織培養学会, 学会賞. 2005.
鬼頭（高橋）典子: [鬼頭典子, 客本斉子, 帖佐直幸.
"ヒト顎下腺由来腺癌細胞株 (HSG) における抗Fas抗体誘導アポトーシスシグナルへのHSP90の関与".]
圭陵会学術振興会研究助成・褒賞, 学術賞, 2004.