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Ohta M.*, Nemoto A.*, Chosa N., Kyakumoto S., Yokota S., Kamo M., Shibata S., Joh S., Satoh K., Ishisaki A. "Toll-like receptor 4-mediated signaling activated by lipopolysaccharide suppresses transforming growth factor-beta-induced nerve growth factor expression in periodontal ligament-derived fibroblasts". Dental Journal of Iwate Medical University, in press. *co-first authors.

Ohta M., Chosa N., Kyakumoto S., Yokota S., Okubo N., Nemoto A., Kamo M., Joh S., Satoh K., Ishisaki A. "IL-1ƒÀ and TNF-ƒ¿ suppress TGF-ƒÀ-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-ƒÀ-induced Smad2/3-, and p38 MAPK-mediated signals". International Journal of Molecular Medicine, in press.

Chosa N., Ishisaki A. "Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin". Japanese Dental Science Review, in press.

Nemoto A., Chosa N., Kyakumoto S., Yokota S., Kamo M., Noda M., Ishisaki A. "Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells". Molecular Medicine Reports, 17:3448-3454, 2018. [PubMed] [FullText] [PDF]

Takizawa N.*, Okubo N.*, Kamo M., Chosa N., Mikami T., Suzuki K., Yokota S., Ibi M., Ohtsuka M., Taira M., Yaegashi T., Ishisaki A., Kyakumoto S. "Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture". Experimental Cell Research, 358:411-420, 2017. *co-first authors. [PubMed] [FullText] [PDF] [Mesenchymal Cell News]

Kanno Y., Maruyama C., Matsuda A., Ishisaki A. "uPA-derived peptide, A6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss". Immunity, Inflammation and Disease, 5:289-299, 2017. [PubMed] [FullText] [PDF]

Kanno Y., Ishisaki A., Kuretake H., Maruyama C., Matsuda A., Matsuo O. "Alpha2-antiplasmin modulates bone formation by negatively regulating the osteoblast differentiation and its function". International Journal of Molecular Medicine, 40:854-858, 2017. [PubMed] [FullText] [PDF]

Inoue M., Yamada J, Aomatsu-Kikuchi E., Satoh K., Kondo H., Ishisaki A., Chosa N. "SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells". Molecular Medicine Reports, 15:4069-4076, 2017. [PubMed] [FullText] [PDF]

Inoue M., Ohtsu K., Ohtsuka M., Takafuji K., Harada H., Ishisaki A., Kondo H. "Healing mechanism surrounding transplanted bone using transgenic mice expressing red fluorescent protein in vivo". Journal of Oral Tissue Engineering, 14:74-85, 2017. [J-STAGE] [PDF]

Yokota S., Chosa N., Kyakumoto S., Kimura H., Ibi M., Kamo M., Satoh K., Ishisaki A. "ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint". International Journal of Molecular Medicine, 39:799-808, 2017. [PubMed] [FullText] [PDF]

Suzuki K.*, Chosa N.*, Sawada S., Takizawa N., Yaegashi T., Ishisaki A. "Enhancement of anti-inflammatory and osteogenic abilities of mesenchymal stem cells via cell-to-cell adhesion to periodontal ligament-derived fibroblasts". Stem Cells International, 2017:3296498, 2017. *co-first authors. [PubMed] [FullText] [PDF]

Chiba T., Ishisaki A., Kyakumoto S., Shibata T., Yamada H., Kamo M. "Transforming growth factor-ƒÀ1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression". Oncology Reports, 37:713-720, 2017. [PubMed] [FullText] [PDF]

Bologna-Molina R., Takeda Y., Kuga T., Chosa N., Kitagawa M., Takata T., Ishisaki A., Mikami T. "Expression of Wilms' tumor 1 (WT1) in ameloblastomas". Journal of Oral Science, 58:407-413, 2016. [PubMed] [FullText] [PDF]

Kanno Y., Ishisaki A., Miyashita M., and Matsuo O. "The blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin ƒÀ3/Akt pathway". Immunity, Inflammation and Disease, 4:338-349, 2016. [PubMed] [FullText] [PDF]

Komatsu Y., Ibi M., Chosa N., Kyakumoto S., Kamo M., Shibata T., Sugiyama Y., Ishisaki A. "Zoledronic acid suppresses transforming growth factor-ƒÀ (TGF-ƒÀ)-induced fibrogenesis by human gingival fibroblasts possibly through down-regulation of TGF-ƒÀ type I receptor expression". International Journal of Molecular Medicine, 38:139-147, 2016. [PubMed] [FullText] [PDF]

Hino M., Kamo M., Saito D., Kyakumoto S., Shibata T., Mizuki H., Ishisaki A. "Transforming growth factor-ƒÀ1 induces invasion ability of HSC-4 human squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signaling axis". Journal of Biochemistry, 159:631-640, 2016. [PubMed] [FullText] [PDF]

Igarashi Y.*, Chosa N.*, Sawada S., Kondo H., Yaegashi T., Ishisaki A. "VEGF-C and TGF-ƒÀ reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes". International Journal of Molecular Medicine, 37:1005-1013, 2016. *co-first authors. [PubMed] [FullText] [PDF]

Sawada S.*, Chosa N.*, Takizawa N., Yokota J., Igarashi Y., Tomoda K., Kondo H., Yaegashi T., Ishisaki A. "Establishment of mesenchymal stem cell lines derived from the bone marrow of GFP-transgenic mice exhibiting diversity in intracellular TGF-ƒÀ and BMP signaling". Molecular Medicine Reports, 13:2023-2031, 2016. *co-first authors. [PubMed] [FullText] [PDF]

Kanno Y., Ishisaki A., Kawashita E., Kuretake H., Ikeda K., Matstuo O. "uPA attenuated LPS-induced inflammatory osteoclastogenesis through the plasmin/PAR-1/Ca2+/CaMKK/AMPK axis". International Journal of Biological Sciences, 12:63-71, 2016. [PubMed] [FullText] [PDF]

Furukawa S.*, Kuwajima Y.*, Chosa N., Satoh K., Ohtsuka M., Miura H., Kimura M., Inoko H., Ishisaki A., Fujimura A., Miura H. "Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice". Experimental and Therapeutic Medicine, 10:1380-1386, 2015. *co-first authors. [PubMed] [FullText] [PDF]

Akazawa Y., Hasegawa T., Yoshimura Y., Chosa N., Asakawa T., Ueda K., Sugimoto A., Kitamura T., Nakagawa H., Ishisaki A., Iwamoto T. "Recruitment of mesenchymal stem cells by stromal cell-derived factor 1ƒ¿ in pulp cells from deciduous teeth". International Journal of Molecular Medicine, 36:442-448, 2015. [PubMed] [FullText] [PDF]

Kuramitsu-Fujimoto S., Saito N., Ariyoshi W., Okinaga T., Kamo M., Ishisaki A., Takata T., Yamaguchi K., and Nishihara T. "Novel biological activity of ameloblastin in enamel matrix derivative". Journal of Applied Oral Science, 23:49-55, 2015. [PubMed] [FullText] [PDF]

Nakajima K., Itoh F., Nakamura M., Kawamura A., Yamazaki T., Kozakai T., Takusari M., Ishisaki A. "Opposing effects of lactoferrin on the proliferation of fibroblasts and epithelial cells from bovine mammary gland". Journal of Dairy Science, 98:1069-1077, 2015. [PubMed]

Taira M., Hatakeyama W., Yokota J., Chosa N., Ishisaki A., Takafuji K., Kihara H., Kondo H., Hattori M. "Tracking GFP-labeled transplanted mouse MSC in nude mice using in vivo fluorescence imaging". Nano Biomedicine, 6:73-77, 2014. [J-STAGE] [PDF]

Tamaoki N., Takahashi K., Aoki H., Iida K., Kawaguchi T., Hatakeyama D., Inden M., Chosa N., Ishisaki A., Kunisada T., Shibata T., Goshima N., Yamanaka S., Tezuka K. "The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells". Scientific Reports, 4:7283, 2014. [PubMed] [FullText] [PDF] [ESC & iPSC News]

Asano T., Taoka M., Yamauchi Y., Everroad C.R., Seto Y., Isobe T., Kamo M., Chosa N. "Re-examination of a ƒ¿-chymotrypsin-solubilized laccase in the pupal cuticle of the silkworm, Bombyx mori: insights into the regulation system for laccase activation during the ecdysis process". Insect Biochemistry and Molecular Biology, 55:61-69, 2014. [PubMed]

Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N. "Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells". Scientific Reports, 4:3652, 2014. [PubMed] [FullText] [PDF] [Faculty of 1000] [Mesenchymal Cell News]

Matsui M., Chosa N., Shimoyama Y., Minami K., Kimura S., Kishi M. "Effects of tongue cleaning on bacterial flora in tongue coating and dental plaque: A crossover study". BMC Oral Health, 14:4, 2014. [PubMed] [FullText] [PDF]

Aomatsu E.*, Chosa N.*, Nishihira S., Sugiyama Y., Miura H., Ishisaki A. "Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRƒÀ in a ligand-independent manner in mesenchymal stem cells". International Journal of Molecular Medicine, 33:565-572, 2014. *co-first authors. [PubMed] [FullText] [PDF]

Yokota J., Chosa N., Sawada S., Okubo N., Takahashi N., Hasegawa T., Kondo H., Ishisaki A. "PDGF-induced PI3K-mediated signal enhances TGF-ƒÀ-induced osteogenic differentiation of human mesenchymal stem cells in the TGF-ƒÀ-activated MEK-dependent manner". International Journal of Molecular Medicine, 33:534-542, 2014. [PubMed] [FullText] [PDF]

Kimura H.*, Okubo N.*, Chosa N., Kyakumoto S., Kamo M., Miura H., Ishisaki A. "EGF positively regulates the proliferation and migration, and negatively regulates the myofibroblast differentiation of periodontal ligament-derived endothelial progenitor cells through MEK/ERK- and JNK-dependent signals". Cellular Physiology and Biochemistry, 32:899-914, 2013. *co-first authors. [PubMed] [FullText] [PDF]

Hatakeyama W., Taira M., Chosa N., Kihara H., Ishisaki A., Kondo H. "Effects of apatite particle size contained in two apatite/collagen composites on osteogenic differentiation profile in osteoblastic cells". International Journal of Molecular Medicine, 32:1255-1261, 2013. [PubMed] [FullText] [PDF]

Sawada S., Chosa N., Ishisaki A., Naruishi K. "Enhancement of gingival inflammation induced by synergism of IL-1ƒÀ and IL-6". Biomedical Research, 43:31-40, 2013. [PubMed] [PDF]

Takizawa N., Sawada S., Chosa N., Ishisaki A., Naruishi K. "Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts". Biomedical Research, 43:1-11, 2013. [PubMed] [PDF]

Saito D., Kyakumoto S., Chosa N., Ibi M., Takahashi N., Okubo N., Sawada S., Ishisaki A., Kamo M. "Transforming growth factor-ƒÀ1 induces epithelial-mesenchymal transition and integrin ƒ¿3ƒÀ1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug". Journal of Biochemistry, 153:303-315, 2013. [PubMed] [PDF]

Mikami T., Hada T., Chosa N., Ishisaki A., Mizuki H., Takeda Y. "Expression of WT1 (Wilmsf tumor 1) in oral squamous cell carcinoma". Journal of Oral Pathology and Medicine, 42:133-139, 2013. [PubMed] [PDF]

Yoshida M.*, Okubo N.*, Chosa N., Hasegawa T., Ibi M., Kamo M., Kyakumoto S., Ishisaki A. "TGF-ƒÀ-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals". International Journal of Biological Sciences, 8:1062-1074, 2012. *co-first authors. [PubMed] [PDF] [GlobalMedicalDiscovery]

Shenton M.R., Berberich T., Kamo M., Yamashita T., Taira H., Terauchi R. "Use of intercellular washing fluid to investigate the secreted proteome of the rice-Magnaporthe interaction". Journal of Plant Research, 125:311-316, 2012. [PubMed] [PDF]

Inoko A., Matsuyama M., Goto H., Ohmuro-Matsuyama Y., Hayashi Y., Enomoto M., Ibi M., Urano T., Yonemura S., Kiyono T., Izawa I., Inagaki M. "Trichoplein and Aurora A block aberrant primary clia assembly in proliferating cells". Journal of Cell Biology, 197:391-405, 2012. [PubMed] [PDF]

Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Fujihara Y., Kitamura T., Tanaka M., Ishisaki A., Mitome M. "Differential effects of TGF-ƒÀ1 and FGF-2 on SDF-1ƒ¿ expression in human periodontal ligament cells derived from deciduous teeth in vitro". International Journal of Molecular Medicine, 30:35-40, 2012. [PubMed] [PDF]

Asakawa T., Chosa N., Yoshimura Y., Asakawa A., Tanaka M., Ishisaki A., Mitome M., Hasegawa T. "Fibroblast growth factor 2 inhibits the expression of stromal cell-derived factor 1ƒ¿ in periodontal ligament cells derived from human permanent teeth in vitro". International Journal of Molecular Medicine, 29:569-573, 2012. [PubMed] [PDF]

Takahashi M., Okubo N., Chosa N., Takahashi N., Ibi M., Kamo M., Mizuki H., Ishisaki A., Kyakumoto S. "Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells". International Journal of Molecular Medicine, 29:357-364, 2012. [PubMed] [PDF]

Takahashi N., Chosa N., Hasegawa T., Nishihira S., Okubo N., Takahashi M., Sugiyama Y., Tanaka M., Ishisaki A. "Dental pulp cells derived from permanent teeth express higher levels of R-cadherin than do deciduous teeth: Implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells". Archives of Oral Biology, 57:44-51, 2012. [PubMed] [PDF]

Nakajima K., Kanno Y., Nakamura M., Gao X-D., Kawamura A., Itoh F., Ishisaki, A. "Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway". Biometals, 24:847-856, 2011. [PubMed] [PDF]

Kanno Y., Ishisaki A., Kawashita E., Chosa N., Nakajima K., Nishihara T., Toyoshima K., Okada K., Ueshima S., Matsushita K., Matsuo O., Matsuno H. "Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function". Journal of Biological Chemistry, 286:8952-8960, 2011. [PubMed] [PDF]

Nishihira S., Okubo N., Takahashi N., Ishisaki A., Sugiyama Y., Chosa N. "High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells". Cell Biology International, 35:475-481, 2011. [PubMed] [PDF]

Ibi M.*, Zou P.*, Inoko A.*, Shiromizu T., Matsuyama M., Hayashi Y., Enomoto M., Mori D., Hirotsune S., Kiyono T., Tsukita S., Goto H., Inagaki M. "Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein". Journal of Cell Science, 124:857-864, 2011. *co-first authors. [PubMed] [PDF]

Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Ishisaki A., Tanaka M. "Establishment of immortalized human periodontal ligament cells derived from deciduous teeth". International Journal of Molecular Medicine, 26:701-705, 2010. [PubMed] [PDF]

Yoshida Y., Ito S., Kamo M., Kezuka Y., Tamura H., Kunimatsu K., Kato H. "Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586". Microbiology, 156:2260-2269, 2010. [PubMed] [PDF]

Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Asakawa A., Ishisaki A., Tanaka M. "Effect of fibroblast growth factor-2 on periodontal ligament cells derived from human deciduous teeth in vitro". Experimental and Therapeutic Medicine, 3:337-341, 2010. [PubMed] [PDF]

Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Asakawa A., Ishisaki A., Tanaka M. "Effect of fibroblast growth factor-2 on dental pulp cells derived from human deciduous teeth in vitro". Experimental and Therapeutic Medicine, 1:477-480, 2010. [PDF]

Okubo N., Ishisaki A., Iizuka T., Tamura M., Kitagawa Y. "Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K-activation-dependent manner". Journal of Vascular Research, 47:369-383, 2010. [PubMed] [PDF]

Nakajima K., Nakamura M., Ishisaki A., Kozakai T. "Synergistic effect of dexamethasone and prolactin on VEGF expression bovine mammary epithelial cells via p44/p42 MAP kinase". Asian-Australasian Journal of Animal Sciences, 22:788-795, 2009. [PDF]

Shirai K., Ishisaki A., Kaku T., Tamura M., Furuichi Y. "Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein". Journal of Periodontal Research, 44:238-247, 2009. [PubMed] [PDF]

Minami A., Fujiwara M., Furuto A., Fukao Y., Yamashita T., Kamo M., Kawamura Y., Uemura M. "Alterations in Detergent-Resistant Plasma Membrane Microdomains in Arabidopsis thaliana During Cold Acclimation". Plant and Cell Physiology, 50:341-359, 2009. [PubMed] [PDF]

Ohta M., Sugano A., Goto S., Yusoff S., Hirota Y., Funakoshi K., Miura K., Maeda E., Takaoka N., Sato N., Ishizuka H., Arizono N., Nishio H., Takaoka Y. "Full-length sequence of mouse acupuncture-induced 1-L (Aig1l) gene including its transcriptional start site". Evidence-based complementary and alternative medicine : eCAM, Epub ahead of print, 2009. [PubMed] [PDF]

Taira M., Chosa N., Sasaki K., SaitohS., Nezu T., Sato N., Araki Y. "Gene expression analyses of human mesenchymal stem cells cultured in osteogenic differentiation medium for 3, 7, 14 and 21 days by genome focus DNA microarray and real-time PCR". Journal of Oral Tissue Engineering, 5:35-47, 2007. [J-STAGE] [PDF]

Takaoka Y.*, Ohta M.*, Ito A., Takamatsu K., Sugano A., Funakoshi K., Takaoka N., Sato N., Arizono N., Goto S., Maeda E. "Electroacupuncture suppresses myostatin gene expression: cell proliferation reaction in mouse skeletal muscle". Physiological Genomics, 30:102-110, 2007. *co-first authors. [PubMed] [PDF]

Jang I.H.*, Chosa N.*, Kim S.H., Nam H.J., Lemaitre B., Ochiai M., Kambris Z., Brun S., Hashimoto C., Ashida M., Brey P.T., Lee W.J. "A Spatzle-processing enzyme is indispensable for Toll signaling activation in Drosophila innate immunity". Developmental Cell, 10:45-55, 2006. *co-first authors. [PubMed] [PDF]

Taira M., Chosa N., Sasaki K., Saitoh S., Nezu T., Sato N., Araki Y. "DNA microarray analyses of gene expression in human mesenchymal stem cells cultured in osteogenic differentiation medium for 14 days". Journal of Oral Tissue Engineering, 3:25-53, 2005. [J-STAGE] [PDF]

Iida T., Kamo M., Uozumi N., Inui T., Imai K. "Further application of a two-step heparin affinity chromatography method using divalent cations as eluents: purification and identification of membrane-bound heparin binding proteins from the mitochondrial fraction of HL-60 cells". Journal of Chromatography B, 823:209-212. 2005. [PubMed]

Chosa N.*, Kyakumoto S.*, Kito N., Kamo M., Sato N. "Mechanism of Fas-mediated cell death and its enhancement by TNF-ƒ¿ in human salivary gland adenocarcinoma cell line HSG". European Journal of Oral Science, 112:338-346, 2004. *co-first authors. [PubMed] [PDF]

Chosa N.*, Taira M.*, Saitoh S., Sato N., Araki Y. "Characterization of apatite formed on alkaline-heat-treated Ti". Journal of Dental Research, 83:465-469, 2004. *co-first authors. [PubMed] [PDF]

Taira M., Chosa N., Saitoh S., Sasaki K., Sato N., Takahashi J., Araki Y. "Effects of the medium type, serum amount and dexamethasone induction on the cell proliferation and alkaline phosphatase activity of twice-passaged SD rats' bone marrow stromal cells". Journal of Oral Tissue Engineering, 1:59-68, 2004. [J-STAGE] [PDF]

Takaoka Y., Ohta M., Miyakawa K., Nakamura O., Suzuki M., Takahashi K., Yamamura K., Sakaki Y. "Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met". American Journal of Pathology, 164:337-345, 2004. [PubMed] [PDF]

Kyakumoto S., Kito N., Sato N. "Expression of cAMP response element binding protein (CREB)-binding protein (CBP) and the implication in retinoic acid-inducible transcription activation in human salivary gland adenocarcinoma cell line HSG". Endocrine Research, 29:277-289, 2003. [PubMed]

Tsugita A., Miyazaki K., Nabetani T., Nozawa T., Kamo M., Kawakami T. "Application of chemical selective cleavage methods to analyze post-translational modification in proteins". Proteomics, 1:1082-1091, 2001. [PubMed]

Seo D., Tomioka A., Kusumoto N., Kamo M., Enami I., Sakurai H. "Purification of ferredoxins and their reaction with purified reaction center complex from the green sulfur bacterium Chlorobium tepidum". Biochimica et Biophysica Acta, 1503:377-384, 2001. [PubMed]

Araki N., Morimasa T., Sakai T., Tokuoh H., Yunoue S., Kamo M., Miyazaki K., Abe K., Saya H., Tsugita A. "Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis". Electrophoresis, 21:1880-1889, 2000. [PubMed]

Tsugita A., Kawakami T., Uchida T., Sakai T., Kamo M., Matsui T., Watanabe Y., Morimasa T., Hosokawa K., Toda T. "Proteome analysis of mouse brain: two-dimensional electrophoresis profiles of tissue proteins during the course of aging". Electrophoresis, 21:1853-1871, 2000. [PubMed]

Nagai M., Kyakumoto S., Sato N. "Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation". Biochemical and Biophysical Research Communications, 269:532-536, 2000. [PubMed]
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’Ÿ²’¼K, ‹e’r-Â¼Œb”üŽq, ¼•½@Œ÷, ‰¡“c, ‚‹´“TŽq, ‹ß“¡®’m, ™ŽR–FŽ÷, ŽO‰YœAs, Îè–¾. "ŠÔ—tŒnŠ²×–E‚Ìstemness‚ðˆÛŽ‚·‚éƒVƒOƒiƒ‹“`’BŒo˜Hi‘àj". ŠâŽèˆã‰È‘åŠwŽ•ŠwŽGŽ, 39:56-65, 2014. [PDF]

ŒK“‡K‹I, ‘å’ː³l, Îè–¾, “¡‘º˜N. "ÔFŒuŒõ‹­”­Œ»ˆâ“`Žq“±“üƒ}ƒEƒX‚É‚¨‚¯‚éŒuŒõ”­Œ»•”ˆÊ‚ÌŒ`‘ÔŠw“IŒŸ“¢". ŠâŽèˆã‰È‘åŠwŽ•ŠwŽGŽ, 37:24-37, 2012. [PDF]

’Ÿ²’¼K, Îè–¾. "œ‚É‚¨‚¯‚錌ŠÇV¶‚Ɛü—nŒni‘àj". “ú–{ŒŒðŽ~ŒŒŠw‰ïŽ, 20:12-17, 2009. [J-STAGE] [PDF]

¬ìŒbŽq, ‰Á–ΐ­°, …ét”ü, ‹q–{ÄŽq. "Mycoplasma salivarium‚É‚¨‚¯‚éƒkƒNƒŒƒA[ƒ[‚Ì‘¶Ý‚Æ‚»‚Ì“Á«". ŠâŽèˆã‰È‘åŠwŽ•ŠwŽGŽ, 33:109-122, 2008. [PDF]

•½‰ë”V, r–Ø‹g”n, ’Ÿ²’¼K, ²“¡ÙŽq. "ƒAƒpƒ^ƒCƒg‚̍œÄ¶ì—pi‘àj". ƒZƒ‰ƒ~ƒbƒNƒX, 43:290-293, 2008.

Š™“cm, ‰Á–ΐ­°, ‹q–{ÄŽq. "Galectin-1‚̓qƒgŒûoG•½ã”çŠà×–E‚̃AƒmƒCƒLƒX‚ð—}§‚·‚é". ŠâŽèˆã‰È‘åŠwŽ•ŠwŽGŽ, 32:157-169, 2007. [PDF]

‰Á–ΐ­°, ‹q–{ÄŽq, ²“¡ÙŽq. "ƒqƒgŠ{‰º‘B—R—ˆ‘BŠà×–EŠ”‚̃vƒƒeƒIƒ~ƒNƒXi‘àj". Œûo‘gD”|—{Šw‰ïŽ, 15:11-28, 2006.

“쏇Žq, ‹q–{ÄŽq, ‰Á–ΐ­°. "ƒRƒ‰[ƒQƒ“ƒXƒ|ƒ“ƒW‚ð—p‚¢‚½ŽOŽŸŒ³”|—{‚É‚¨‚¯‚éƒqƒgŠ{‰º‘B—R—ˆ‘BŠà×–EŠ”‚̈â“`Žq”­Œ»". ŠâŽèˆã‰È‘åŠwŽ•ŠwŽGŽ, 30:216-227, 2005. [PDF]

‹S“ª“TŽq, ‹q–{ÄŽq, ’Ÿ²’¼K. "ƒqƒgŠ{‰º‘B—R—ˆ‘BŠà×–EŠ” (HSG) ‚É‚¨‚¯‚éRFasR‘Ì—U“±ƒAƒ|ƒg[ƒVƒXƒVƒOƒiƒ‹‚Ö‚ÌHSP90‚ÌŠÖ—^". Journal of Oral Biosciences, 46:229-242, 2004. [J-STAGE] [PDF]

‰Á–ΐ­°, ‹q–{ÄŽq, ’Ÿ²’¼K, ²“¡ÙŽq. "ƒvƒƒeƒI[ƒ€‰ðÍ‚É‚æ‚éƒqƒgŠ{‰º‘B—R—ˆ‘BŠà×–EŠ”‚Æ‚»‚Ì”h¶×–EŠ”‚É‚¨‚¯‚é”­Œ»ƒ^ƒ“ƒpƒNŽ¿‚Ì”äŠr". Œûo‘gD”|—{Šw‰ïŽ, 9:31-42, 2000.

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Okubo N., Ishisaki A. "Angiogenic capacity of periodontal ligament-derived stem cells". [Advances in oral tissue engineering. Murata M. & Um IW. (ed.)] Quintessence Publishing, pp9-14, 2014. [Publisher] [Amazon]

Hasegawa T., Chosa N., Asakawa T., Yoshimura Y., Ishisaki A., Tanaka M. "Eatablishment of periodontal ligament cell line derived from human deciduous teeth". [Interface oral health science 2011. Sasaki, K. (ed.)] Springer, New York, pp114-116, 2012. [Publisher] [Amazon]

Asakawa T., Chosa N., Hasegawa T., Asakawa A., Ishisaki A., Tanaka M. "Regulation of SDF-1 expression in periodontal ligament cells derived from human permanent teeth". [Interface oral health science 2011. Sasaki, K. (ed.)] Springer, New York, pp107-109, 2012. [Publisher] [Amazon]

Îè–¾: [‘ì‘¾˜Y, {“c—§—Y, –؍莡r ŠÄC.@"Œûo¶‰»Šw (‘æ5”Å)".]@ˆãŽ•–òo”ÅŠ”Ž®‰ïŽÐ. 2011. [Publisher] [Amazon]

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ŽóÜEµ‘ҍu‰‰“™


‹e’r-Â¼Œb”üŽq: [Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N. "Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2014.

Îè–¾. "ƒXƒtƒFƒƒCƒh”|—{–@‚ð—p‚¢‚½Ž•Žüx‘Ñ—R—ˆ×–E‚É‚æ‚錌ŠÇ‘gDŒ`¬‚ÌŽŽ‚Ý". ‘æ50‰ñ“ú–{Œûo‘gD”|—{Šw‰ï, µ‘ҍu‰‰, 2013.

‹g“cää»Žq: [Yoshida M., Okubo N., Chosa N., Hasegawa T., Ibi M., Kamo M., Kyakumoto S., Ishisaki A. "TGF-ƒÀ-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2013.

àV“cr•ã: [Sawada S., Chosa N., Ishisaki A., Naruishi K. "Enhancement of gingival inflammation induced by synergism of IL-1ƒÀ and IL-6".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2013.

Îè–¾. "×–E‘BˆöŽq‚É‚æ‚éŠÔ—tŒnŠ²×–E/‘O‹ì×–E‚Ì‘BE•ª‰»’²ß‚ðŠî”Õ‚Æ‚µ‚½V‚½‚ȍжˆã—ÃŽ÷—§‚ÌŽŽ‚Ý". ‘æ31‰ñÁ‰»Ší•a‘Ԑ¶—•×‹­‰ï, µ‘ҍu‰‰, 2012.

‚‹´”üŽq: [Takahashi M., Okubo N., Chosa N., Takahashi N., Ibi M., Kamo M., Mizuki H., Ishisaki A., Kyakumoto S. "Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2012.

¼•½@Œ÷: [Nishihira S., Okubo N., Takahashi N., Ishisaki A., Sugiyama Y., Chosa N. "High-cell density-induced VCAM1 expression inhibits the migratory ability of mesenchymal stem cells".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2012.

Îè–¾. "Elucidation of the molecular mechanisms underlying the ligand-controlled growth and differentiation of mesenchymal stem/progenitor cells: study on the establishment of novel cell therapy for construction of a vascular system". ‘æ37‰ñ“ú–{”÷¬zŠÂŠw‰ï‘‰ï, ƒVƒ“ƒ|ƒWƒXƒg, 2012.

‘å‹v•Û’¼“o. "Ž•ª–Œ—R—ˆŠ²×–E‚É‚æ‚錌ŠÇ“à”ç×–Eƒ}[ƒJ[—z«ŒŒŠÇ\‘¢‚̍\’z". –kŠC“¹Ž•Šw‰ï, –kŠC“¹Ž•Šw‰ïÜ, 2011.

Îè–¾. "–¢•ª‰»ŠÔ—tŒn×–E‚Ì‘BE•ª‰»§ŒäƒƒJƒjƒYƒ€‚̉𖾠\Ž•ŽüèՑэжˆã—Â̎ÀŒ»‚ð–ÚŽw‚µ‚ā\". Œûoæ’[‰ž—pˆã‰ÈŠwŒ¤‹†‰ï, µ‘ҍu‰‰, 2011.

‘å‹v•Û’¼“o, Îè–¾. "ƒ‰ƒbƒgŽ•ª–Œ—R—ˆ–¢•ª‰»ŠÔ—tŒn×–E‚É‚æ‚錌ŠÇ—l\‘¢•¨‚ÌŒ`¬". ŠâŽèˆã‰È‘åŠwŽ•Šw‰ï, —DG”­•\Ü, 2010.

‘å‹v•Û’¼“o, “c‘º³l, –kì‘P­, ‰Á–ΐ­°, ‹q–{ÄŽq, ’Ÿ²’¼K, ‚‹´“TŽq, ”ђː³, Îè–¾. "ƒ‰ƒbƒgŽ•ª–Œ—R—ˆŠÔ—tŒnŠ²×–E—l×–E‚É‚æ‚éPI3K/AktˆË‘¶“I‚ÈTie-2—z«ŒŒŠÇ\‘¢‚ÌŒ`¬". Œûoæ’[‰ž—pˆã‰ÈŠwŒ¤‹†‰ï, Ä¶•â’ÔˆãŠw‰ïŽáŽèÜƒtƒ@ƒCƒiƒŠƒXƒg, 2009.

”’ˆä—v: [Shirai K., Ishisaki A., Kaku T., Tamura M., Furuichi Y. "Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein".] “ú–{Ž•Žü•aŠw‰ï, §—ãÜ, 2009.

Îè–¾, ’Ÿ²’¼K. "FGF‚ÆTGF-ƒÀƒX[ƒp[ƒtƒ@ƒ~ƒŠ[‚Ì‘ŠŒÝì—p‚É‚æ‚é–¢•ª‰»ŠÔ—tŒn×–E‚̍זE‘BE•ª‰»§Œä‹@\‚̉ð–¾". Œûoˆã‰ÈŠwƒtƒƒ“ƒeƒBƒAŠwpW‰ï, µ‘ҍu‰‰, 2009.

‘å‹v•Û’¼“o, “c‘º³l, ”ђː³, ‰Á–ΐ­°, ‹q–{ÄŽq, ’Ÿ²’¼K, ‚‹´“TŽq, –kì‘P­, Îè–¾. "Ž•ª–Œ—R—ˆŠ²×–E‚É‚æ‚錌ŠÇ“à”ç×–Eƒ}[ƒJ[—z«ŒŒŠÇ\‘¢‚ÌŒ`¬". d‘gDÄ¶¶•¨Šw‰ï, —DGƒ|ƒXƒ^[Ü, 2008.

¬ìŒbŽq: [¬ìŒbŽq, ‰Á–ΐ­°, …ét”ü, ‹q–{ÄŽq. "Mycoplasma salivarium‚É‚¨‚¯‚éƒkƒNƒŒƒA[ƒ[‚Ì‘¶Ý‚Æ‚»‚Ì“Á«".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2008.

Š™“cm: [Š™“cm, ‰Á–ΐ­°, ‹q–{ÄŽq. "Galectin-1‚̓qƒgŒûoG•½ã”çŠà×–E‚̃AƒmƒCƒLƒX‚ð—}§‚·‚é".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2007.

²“¡ÙŽq. “ú–{Œûo‘gD”|—{Šw‰ï, Šw‰ïÜ. 2005.

‹S“ªi‚‹´j“TŽq: [‹S“ª“TŽq, ‹q–{ÄŽq, ’Ÿ²’¼K. "ƒqƒgŠ{‰º‘B—R—ˆ‘BŠà×–EŠ” (HSG) ‚É‚¨‚¯‚éRFasR‘Ì—U“±ƒAƒ|ƒg[ƒVƒXƒVƒOƒiƒ‹‚Ö‚ÌHSP90‚ÌŠÖ—^".] Œ\—ˉïŠwpU‹»‰ïŒ¤‹†•¬E–JÜ, ŠwpÜ, 2004.

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