CATALYTIC ACTIVITY: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH. * PATHWAY: Serine biosynthesis; first step. * SUBUNIT: Homotetramer (By similarity). * DISEASE: Defects in PHGDH are the cause of a deficiency characterized by congenital microcephaly, psychomotor retardation, and seizures. * SIMILARITY: BELONGS TO THE D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASES FAMILY. |
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06-DEC-00
Last Update 13-Mar-03