CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate. * COFACTOR: REQUIRES MAGNESIUM AND POTASSIUM. * PATHWAY: Glycolysis; final step. * SUBUNIT: Homotetramer. * ALTERNATIVE PRODUCTS: 2 isoforms; M1 (shown here) and M2 (AC P14786); are produced by alternative splicing. * MISCELLANEOUS: THERE ARE 4 ISOZYMES OF PYRUVATE KINASE IN MAMMALS: L, R, M1 AND M2. L TYPE IS MAJOR ISOZYME IN THE LIVER, R IS FOUND IN RED CELLS, M1 IS THE MAIN FORM IN MUSCLE, HEART AND BRAIN, AND M2 IS FOUND IN EARLY FETAL TISSUES. * SIMILARITY: BELONGS TO THE PYRUVATE KINASE FAMILY. |
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07-NOV-00
Last Update 13-Mar-03